Hyperglycemia is associated with increased morbidity and mortality rates in neonates with necrotizing enterocolitis
Section snippets
Materials and methods
The study was approved by our institutional research ethics committee. The subjects for this review were 95 consecutive neonates with confirmed NEC (Bell stage II or III9) admitted to the surgical intensive care unit (ICU) over a 5-year period. All infants were transferred in to our ICU from referring hospitals, and no infants were inborn. All blood glucose measurements (n = 6,508) taken from these neonates were retrieved from a departmental clinical database (CareVue, Philips Medical Systems,
Results
The demographic details of the 95 infants with a confirmed diagnosis of NEC are summarized in Table 1. Of these, 2 had 2 episodes of NEC, and 1 had 3 episodes. Each admission episode was considered separately resulting in a total of 99 admission episodes. Outcome was discharge in 67 episodes (66%) and death in the remaining 32 (34%). Sixty-eight infants required surgery during the course of their ICU admission for acute NEC. Of these, 11 infants were found to have panintestinal NEC at
Discussion
We have identified a high incidence of hyperglycaemia in infants with NEC, a finding that has not been reported previously. Associated with hyperglycemia is an increase in late mortality and a tendency for longer ICU stay. Although longer ICU stay may simply increase the chance of hyperglycemia occurring, this association between hyperglycemia and poor outcome has been reported in critically ill adult patients and more recently in a pediatric intensive care unit setting.10
The nature of the
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