Original ArticlesImpact of Blood Donor Sex on Transfusion-Related Outcomes in Preterm Infants
Section snippets
Methods
The Institutional Review Board at Women and Infants Hospital reviewed this exploratory, cohort study and granted a waiver of consent for the retrospective review of medical records. The study was conducted at an academic, freestanding, specialty hospital with >8000 deliveries per year and a level IV NICU with >1200 admissions annually.
All NICU patients who received blood product transfusions (packed red blood cells, platelets, or plasma) were identified in the following manner: the hospital
Results
In total, 2418 patients were admitted to the NICU with date of birth January 1, 2009-December 31, 2010. During that time period, 1026 blood transfusions were administered to 248 patients (mean 4.1; range 1-41). Compared with term infants, infants born at 32-336/7 weeks of gestation and 34-366/7 weeks of gestation were not more likely to be transfused OR 0.64; CI = 0.34-1.19 and 1.01; CI = 0.51-1.99, respectively. However, the odds of being transfused if born at <32 weeks of gestation was
Discussion
In this exploratory, retrospective, cohort study, we demonstrate an association between the transfusion of female blood and increased rates of BPD and SIP/NEC in preterm infants born at <32 weeks of gestation. We additionally report an association between transfusion of female blood and a higher composite rate of death or major neonatal morbidities. These findings appear consistent with adult studies linking transfusion of female donor plasma to higher incidence of transfusion- associated lung
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Blood Donor Sex and Outcomes in Transfused Infants
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2023, Transfusion and Apheresis ScienceSex specificity in neonatal diseases
2023, Principles of Gender-Specific Medicine: Sex and Gender-Specific Biology in the Postgenomic EraOn the Gendering of Plasma: What is Transfusion-Related Acute Lung Injury to Bronchopulmonary Dysplasia?
2018, Journal of PediatricsNew frontiers in neonatal red blood cell transfusion research
2023, Journal of Perinatology
The authors declare no conflicts of interest.
Portions of this study were presented at the Pediatric Academic Societies annual meeting, April 25-28, 2015, San Diego, California.