Original ArticlesRelationship between Measures of Neonatal Glycemia, Neonatal Illness, and 2-Year Outcomes in Very Preterm Infants
Section snippets
Methods
Eligible infants were born weighing <1500 g or at <30 weeks of gestation and admitted to the National Women's Health, Auckland City Hospital neonatal intensive care unit (NICU) from July 2005 to October 2008. Infants were excluded if they were admitted to the NICU after 24 hours of age, died or were discharged before day 7, or had a significant congenital abnormality.
The usual clinical practice during the study period was to start intravenous 10% dextrose at 60-90 mL/kg/day as soon as possible
Results
During the study period, 536 eligible infants were admitted to the NICU, of whom 443 (83%) had glucose profiles available for analysis and 346 (65%) had a 2-year developmental assessment available (Figure).
Of participants whose glucose profiles were available for analysis, 287 of the 443 (65%) were categorized as normoglycemic (Table I). Infants in the hypoglycemic category (42/443, 9%) were of similar gestational age and birth weight to those in the normoglycemic category. Infants in the
Discussion
In this cohort of very preterm and very low birth weight infants, absolute glycemic excursions were strongly associated with birth weight, gestational age, intrauterine growth, and illness severity as indicated by CRIB II scores. In general, infants with normal growth were more likely to have normoglycemic glucose profiles, whereas hypoglycemia was seen in more growth-restricted infants, and hyperglycemia was more likely in smaller and sicker infants. Unstable glucose profiles were more likely
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