Original ArticleRespiratory Outcomes of the Surfactant Positive Pressure and Oximetry Randomized Trial (SUPPORT)
Section snippets
Methods
Infants eligible for the Breathing Outcomes Study were infants enrolled in SUPPORT who survived to hospital discharge and consented for enrollment into the study. A total of 1316 infants from 20 centers across the US were enrolled into SUPPORT between February 2005 and February 2009 and seen at follow-up between 2006 and 2011. As a secondary study to SUPPORT, the Breathing Outcomes Study gained approval and began recruitment after SUPPORT began enrollment. As a result, not all SUPPORT
Results
Of the 1316 patients enrolled in SUPPORT, 922 were eligible and provided consent to participate in the Breathing Outcomes Study. The 918 patients with at least 1 completed questionnaire composed the study cohort. Follow-up rates at each time point are listed in the Figure (available at www.jpeds.com).
Among the follow-up cohort, the group randomized to lower oxygen saturation targets had fewer non-Hispanic white patients and a lower proportion of patients with BPD defined using the traditional
Discussion
We report results of the Breathing Outcomes Study, a secondary study to SUPPORT, which sought to quantify respiratory morbidity by 18-22 months CA for extremely premature children born at 24-27 weeks gestation. We found no significant differences at 18-22 months CA in the incidence of either of the 2 primary outcomes (wheezing more than twice per week during the worst 2 week period or cough lasting more than 3 days without a cold) between the lower and higher oxygen saturation target groups or
References (36)
- et al.
Rehospitalization in the first year of life among infants with bronchopulmonary dysplasia
J Pediatr
(2004) - et al.
Tucson Children's Respiratory Study: 1980 to present
J Allergy Clin Immunol
(2003) - et al.
One-year follow-up of 273 infants with birth weights of 700 to 1100 grams after prophylactic treatment of respiratory distress syndrome with synthetic surfactant or air placebo
J Pediatr
(1995) - et al.
Respiratory morbidity in preschool children born prematurely: relationship to adverse neonatal events
Acta Paediatr
(1996) - et al.
Frequent wheeze at follow-up of very preterm infants: which factors are predictive?
Arch Dis Child Fetal Neonatal Ed
(2003) - et al.
Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia
Pediatrics
(2005) - et al.
Pulmonary testing using peak flow meters of very low birth weight children born in the perisurfactant era and school controls at age 10 years
Pediatr Pulmonol
(2007) - et al.
Respiratory health in a total very low birth weight cohort and their classroom controls
Arch Dis Child
(1996) - et al.
Asthma, lung function, and allergy in 12-year-old children with very low birth weight: a prospective study
Pediatr Allergy Immunol
(2003) - et al.
Impact of low birth weight on early childhood asthma in the United States
Arch Pediatr Adolesc Med
(2001)
Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice
Am J Respir Crit Care Med
Effect of cumulative oxygen exposure on respiratory symptoms during infancy among VLBW infants without bronchopulmonary dysplasia
Pediatr Pulmonol
Birth weight <1501 g and respiratory health at age 14
Arch Dis Child
Early CPAP versus surfactant in extremely preterm infants
N Engl J Med
Target ranges of oxygen saturation in extremely preterm infants
N Engl J Med
Neurodevelopmental outcomes in the early CPAP and pulse oximetry trial
N Engl J Med
Safety, reliability, and validity of a physiologic definition of bronchopulmonary dysplasia
J Perinatol
How well they remember: the accuracy of parent reports
Arch Pediatr Adolesc Med
Cited by (110)
Alternative routes of surfactant application – An update
2023, Seminars in Fetal and Neonatal MedicineSurfactant delivery strategies to prevent bronchopulmonary dysplasia
2023, Seminars in PerinatologyOutpatient management of established bronchopulmonary dysplasia: An update
2023, Seminars in PerinatologyInvasive and Noninvasive Ventilation Strategies
2023, Principles of NeonatologyRespiratory Distress Syndrome
2023, Principles of Neonatology
Supported by the National Institutes of Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Heart, Lung, and Blood Institute (recruitment 2004-2009; follow-up 2006-2011). T.S. was supported by the NICHD (SUPPORT Breathing Outcomes Secondary Protocol K23 HD50646). Data collected at participating sites of the NICHD Neonatal Research Network were transmitted to RTI International, the data coordinating center for the network, which stored, managed, and analyzed the data for this study. The authors declare no conflicts of interest.
Registered with ClinicalTrials.gov: NCT00233324.
- ∗
Current affiliation: Children's Hospital at Providence, Anchorage, AK.
- †
A list of members of the SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network is available at www.jpeds.com (Appendix).