EditorialTiming of Caffeine Therapy in Very Low Birth Weight Infants
References (14)
- et al.
Efficacy of caffeine in treatment of apnea in the low-birth-weight infant
J Pediatr
(1977) Methylxanthine therapy in premature infants: sound practice, disaster, or fruitless byway?
J Pediatr
(1999)- et al.
Apnoeic attacks in the newborn treated with aminophylline
Arch Dis Child
(1973) - et al.
Caffeine therapy for apnea of prematurity
N Engl J Med
(2006) - et al.
Long-term effects of caffeine therapy for apnea of prematurity
N Engl J Med
(2007) - et al.
Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity
JAMA
(2012) - et al.
Economic evaluation of caffeine for apnea of prematurity
Pediatrics
(2011)
Cited by (22)
Caffeine for Apnea of Prematurity: Too Much or Too Little of a Good Thing
2023, Journal of PediatricsWeaning and extubation from mechanical ventilation
2022, Goldsmith's Assisted Ventilation of the Neonate: An Evidence-Based Approach to Newborn Respiratory Care, Seventh EditionNational and international guidelines for neonatal caffeine use: Are they evidenced-based?
2020, Seminars in Fetal and Neonatal MedicineCitation Excerpt :The observational studies suggest that caffeine initiated prior to three days of age in preterm infants, especially to those requiring positive airway pressure, is associated with greater benefit, but these data are confounded by indication. It remains unclear whether the safety and benefits of caffeine extend to extremely preterm infants who are fully dependent on mechanical ventilation in the first few days after birth, and who may have not met criteria for inclusion in the CAP trial [19]. Caffeine citrate as administered in the CAP trial was within the standard recommended dose (20 mg/kg loading, 5–10 mg/kg daily dose).
Drugs for the Prevention and Treatment of Bronchopulmonary Dysplasia
2019, Clinics in PerinatologyCitation Excerpt :Moreover, a nonsignificant trend toward higher mortality was observed in the early caffeine group, which led to early closure of the trial. At present, caffeine should be reserved for those neonates with apnea of prematurity or those who are ready for extubation or with significant lung disease.46 The currently available pharmacologic agents used to treat evolving or established BPD are summarized in Table 2.
Bronchopulmonary Dysplasia
2018, Avery's Diseases of the Newborn: Tenth EditionBronchopulmonary Dysplasia
2017, Avery's Diseases of the Newborn, Tenth Edition
The authors declare no conflicts of interest.