Original ArticleRandomized Crossover Study of Neurally Adjusted Ventilatory Assist in Preterm Infants
Section snippets
Methods
A prospective, randomized, controlled, crossover comparison of NAVA and SIMV with PS was conducted from March-August of 2011 in the neonatal intensive care unit of Seoul National University Children's Hospital in Seoul, Korea. Approval for this study was obtained by the Seoul National University Hospital Institutional Review Board, and written informed consent was obtained from the parents of neonates prior to their enrollment in this study. This study was conducted in compliance with the
Results
Of the 26 preterm infants enrolled, 2 patients were excluded prior to the study, and 5 patients discontinued the protocol because they met a criterion for termination during the study. The remaining 19 patients completed the 9-hour crossover comparison study (Figure 2).
One of the 5 patients was terminated after initiation of the protocol because the parents withdrew their consent for the study. For the remaining 4, tachypnea (RR >80/min) developed. Tachypnea developed in 3 of the patients
Discussion
The present study showed that NAVA lowered the delivered PIP with a decrease in the EAdi and lowered the respiratory work while maintaining an equivalent supply of oxygen and gas exchange relative to SIMV with PS. Although the absolute reduction of inspiratory pressure was small, the difference is probably significant because our study was conducted over a relatively short 4-hour period. Recently, Stein at al19 reported a retrospective analysis, which demonstrated NAVA provided better blood gas
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Supported by the Research and Development Project of Korea Health Industry Development Institute, Ministry of Health and Welfare, Republic of Korea (A080588-1122-1260200). The authors declare no conflicts of interest.
Registered with ClinicalTrials.gov: NCT01389882.