Original ContributionDeterminants of oxidant stress in extremely low birth weight premature infants
Section snippets
Materials and methods
A prospective study comparing the effects of the mode of TPN delivery on antioxidant status was conducted in premature infants in the neonatal intensive care unit at the Children's and Women's Health Centre of British Columbia from 2006 to 2009. Once the infant reached full TPN, urine and blood were sampled 72 h apart on postnatal day 7 (sample 1, S1) and postnatal day 10 (± 24 h; sample 2, S2). In blood, the redox potential of glutathione and the levels of antioxidant vitamins A and E were
Results
Of the 126 eligible subjects, consent was obtained for 56 and they were distributed by chance to one of the three TPN protocols. Three patients in the AA group and one in the LE group died before sampling because of complications of extreme prematurity. Of the 52 subjects completing the study, 16 received the AA modality, 17 the LE regimen, and 19 the LP modality. The clinical characteristics were similar between the three groups (Table 1); so were the nutrient intakes (intravenous + enteral;
Discussion
We have compared markers of protein oxidation, lipid peroxidation, and overall redox balance in a population at high risk of oxidant stress. We found that oxygen and the TPN modality, to a lesser degree, contributed to the redox status of very premature infants. The later occurs independent of the antioxidant vitamin status. Results in Table 3 confirm that premature infants are subjected to a greater oxidant stress than adult subjects [27], [34], [35], [36]. The biological significance of the
Acknowledgment
This work was supported by the Canadian Institutes of Health Research (MOP 79403).
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2019, Free Radical Biology and MedicineCitation Excerpt :Mortality, an all-encompassing outcome is commonly used when comparing populations of premature infants. Four studies with a total of 800 infants [39,49,120,146] were included in this meta-analysis after using the following key words: premature newborns, PN, photo-protection, shielding from light, randomization, mortality or death. Mortality was half in the light-protected group (95% confidence interval, 0.32–0.87).
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