Efficacy and tolerability of enteral formulations of ibuprofen in the treatment of patent ductus arteriosus in preterm infants
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Cited by (18)
Oral ibuprofen promoted cholestatic liver disease in very low birth weight infants with patent ductus arteriosus
2021, Clinics and Research in Hepatology and GastroenterologyCitation Excerpt :A systematic review of the prevention of PDA using oral ibuprofen in premature infants indicated an increased risk of gastrointestinal bleeding (GIB) (number needed to treat to harm, NNTH = 4), and the incidence of GIB in an oral ibuprofen group was 47.17% (25/53) [10]. Another study suggested that the incidence of necrotizing enterocolitis (NEC) caused by oral ibuprofen in premature infants was 16%, while the incidence of NEC was only 8% in an intravenous ibuprofen group [13] because of the high osmolality and direct effects of oral dosage forms on gastrointestinal mucous membranes. Although there are intravenous dosage forms of ibuprofen in Europe, 29% of premature infants with hsPDA are still treated with oral ibuprofen since it is 60–70 times less expensive than intravenous dosage forms [6].
Repeated Courses of Oral Ibuprofen in Premature Infants with Patent Ductus Arteriosus: Efficacy and Safety
2017, Pediatrics and NeonatologyCitation Excerpt :The present study provides important information about the PDA closure rates in preterm infants who received single or multiple courses of OIBU for closure of hsPDA. After the first course of treatment with OIBU, the PDA closure rate was reported as between 77% and 100%.10–18 If the PDA does not close with pharmacological therapy, surgical ligation is the treatment of choice.
Oral ibuprofen versus intravenous indomethacin for closure of patent ductus arteriosus in very low birth weight infants
2012, Pediatrics and NeonatologyCitation Excerpt :None of the infants who received oral ibuprofen treatment in our study showed evidence of bowel perforation. The rate of NEC among our infants who received enteral ibuprofen was similar to that reported by Tulin et al,22 but it was below the overall rate reported for intravenous ibuprofen [27/356 (8%)] in a recent meta-analysis of studies on preterm infants with HsPDA.34 In our infants, the drug was given undiluted through a feeding tube in a very small volume followed by flushing with distilled water.
Evidence-Based Use of Indomethacin and Ibuprofen in the Neonatal Intensive Care Unit
2012, Clinics in PerinatologyCitation Excerpt :Additionally, peak plasma concentrations are reportedly not as high as those with IV, suggesting that a higher milligram-per-kilogram dosing regimen might be necessary. However, the longer half-life in infants, larger AUC24, and adequate absorption, all factors that contribute to more contact time with the ductus, may explain the better response rates seen in recent studies investigating enteral ibuprofen.70–74 In summary, larger studies with improved design are needed that are powered to detect both closure and complication rates between oral and IV ibuprofen, as well as additional pharmacokinetic data to determine the optimal dosing scheme.