Clinical InvestigationImaging and Diagnostic TestingElevated plasma N-terminal pro–brain natriuretic peptide levels in acute ischemic stroke
Section snippets
Methods
A total of 57 consecutive patients who were admitted to our neurological intensive care unit between October 2003 and May 2004 within the first 24 hours of an AIS were included as the study group. The diagnosis of AIS was established both clinically and radiologically (computed tomography [CT] or magnetic resonance imaging [MRI]). A total of 57 age- and gender-matched healthy individuals were included as controls. Focal or global loss of brain functions lasting for >24 hours and causing
Patient characteristics
There were 37 female and 20 male AIS patients in the study, with a mean age of 64.5 ± 11.3 years (range 35-85). Control group consisted of 36 female and 21 male patients, with a similar mean age of 61.3 ± 6.09 years (range 36-71) (P > .05). Forty-three patients (75%) with AIS had hypertension, and 11 (19%) had diabetes mellitus. Thirteen patients (23%) were active smokers. Twenty-three patients (40%) had insular cortex involvement in CT or MR images, and the diameter of the infarct was >3 cm in
Discussion
To our knowledge, our study is the first to report a significant increase in NT-proBNP levels in patients with AIS. This increase is at the highest level on the first day of AIS and declines significantly on the following days. Importantly, some patients had elevated NT-proBNP levels even if their LVEF was preserved. This observation suggests that increase in NT-proBNP is not limited to primary cardiac conditions, and they may also be elevated in AIS, as they may in pulmonary embolism,12 cor
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Atrial Fibrillation, thromboembolic risk, and the potential role of the natriuretic peptides, a focus on BNP and NT-proBNP – A narrative review
2022, IJC Heart and VasculatureCitation Excerpt :Baseline natriuretic peptide(NP)s have been shown to predict stroke, with N-Terminal Pro Brain Natriuretic Peptide (NT-proBNP) levels correlating to the degree of arteriosclerosis[33] and carotid plaque burden[34], both of which are associated with ischaemic stroke[35,36]. They are also frequently and significantly increased after an acute ischemic stroke[37,38], even when adjusted for age and sex[39]. Similarly, mid regional pro-atrial natriuretic peptide (MR-proANP) has been identified as a biomarker of CE(cardioembolic) stroke but not small vessel cerebral disease, with at least similar associations to both NT-proBNP and Brain Natriuretic Peptide (BNP)[40].
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2017, Journal of the Neurological SciencesElevated Troponin Levels in Acute Stroke Patients Predict Long-term Mortality
2015, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :Thus, we cannot disregard the possibility that silent myocardial infarctions could have contributed to the poor prognosis of these patients and that troponin may be a marker of unstable atherosclerotic disease. Indeed, ST segment deviations, suggestive of myocardial ischemia, were significantly more common in patients with elevated cTnI, which is in line with previous studies.1,11,22-25 A substantial amount of stroke patients (26%) have been shown to have asymptomatic coronary artery stenosis more than 50%, indicating CAD7 and pre-existing CAD in stroke patients may result in a higher vulnerability to myocardial injury.
Plasma Brain Natriuretic Peptide is a Marker of Prognostic Functional Outcome in Non-Cardioembolic Infarction
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