Trends in Endocrinology & Metabolism
Brief reviewThyroid-specific enhancer-binding protein: Role in thyroid function and organogenesis
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Cited by (29)
Role of thyroid transcription factor-1 in transcriptional regulation of heme oxygenase-1
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :TTF-1 was first identified in the thyroid gland [16] and was also reported as Nkx2.1, a member of the Nkx family of homeobox genes and as thyroid-specific enhancer-binding protein (T/EBP). TTF-1 is critical for the differentiation and morphogenesis of the embryonic lung, thyroid, and diencephalon [17,18]. TTF-1 is expressed in the diencephalic regions of the postnatal rodent brain and in hypothalamic cells such as neurons, astroglial cells, and tanycytes, where it regulates synthesis of neuropeptides and proteins involved in control of body homeostasis [19–24].
Thyroglobulin represents a novel molecular architecture of vertebrates
2016, Journal of Biological ChemistryCitation Excerpt :Indeed, in the pharyngeal area of the lamprey larva (the ammocoete), there is an exocrine secretion of iodoprotein containing THs (50) through the endostyle, the longitudinal ciliated groove on the ventral wall of the pharynx. The endostyle may be considered as the equivalent of the thyroid gland as it expresses TTF1/Nkx-2.1, a transcription factor that, along with Pax-8, is required for thyroid specification (51). During metamorphosis, the endostyle becomes reorganized into a true endocrine thyroid gland (37, 50, 52).
Structure-function relationships in pulmonary surfactant membranes: From biophysics to therapy
2014, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :As stated before, TTF-1 is the transcriptional factor that induces SP-A, SP-B and SP-C expression. Complete lack of TTF-1 results in death due to impaired lung development [187], including surfactant protein deficiency [188]. Moreover, a reduction in TTF-1 phosphorylation levels changes the regulation of cell differentiation and causes a down-regulation of SP-A, SP-B and SP-C production.
Neonatal screening for congenital hypothyroidism
1998, Seminars in Neonatology