Mémoire originalAllongement de l'espace QT sous cisapride chez le nouveau-né et le nourrissonLong QT interval under cisapride in neonates and infants
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2006, Annales de Cardiologie et d'AngeiologieDevelopment of a safe and effective pediatric dosing regimen for sotalol based on population pharmacokinetics and pharmacodynamics in children with supraventricular tachycardia
2005, Journal of the American College of CardiologyCitation Excerpt :This is of importance because there is a common mechanism of drug-induced QT prolongation (12), meaning that not only sotalol but also other cardiac or noncardiac drugs with the same mechanism of action might behave similarly in neonates. Hence, the results might explain conflicting data concerning QT interval prolongation in the pediatric population reported from other drugs, such as cisapride (25,26), or it might be helpful in predicting such effects for future applications of drugs (12). Saul et al. (8) did not detect PD age-dependent differences in QT interval prolongation.
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