The Prevention of Rh Immunization
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Cited by (132)
D or anti-D!!! Unblocking the dilemma of blocking-D phenomenon using acid elution
2022, Transfusion and Apheresis ScienceMissed anti-D immune globulin administration to postpartum patients in 2 health systems: an unrecognized patient safety risk
2022, AJOG Global ReportsCitation Excerpt :Anti-D immune globulin (RHIG), a human plasma derivative, can prevent alloimmunization in Rh-negative patients who deliver Rh-positive infants. Despite an unclear mechanism, postpartum anti-D prophylaxis is highly effective and reduces the rate of alloimmunization to only 1% to 2%.3 With an additional prophylactic administration at 28 weeks’ gestation, this rate can be lowered even further to 0.1%.4
Hemolytic Disease of the Fetus and Newborn: Historical and Current State
2021, Clinics in Laboratory MedicineRhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates
2020, Transfusion and Apheresis ScienceCitation Excerpt :RhIg is not indicated in women who are alloimmunized already, since RhIg is not able to revoke any previous immunization [6]. Retrospective cohort-studies with historical control groups revealed that routine antenatal anti-D prophylaxis at the end of the 2nd or at the beginning of the 3rd trimenon is able to reduce the anti-D immunization rate after pregnancy of a RhD negative woman with an RhD positive child from 0.8 to 1.5 % to about 0.1 – 0.2 % [1,17]. A meta-analysis adjusted for differences in study design and quality showed a reduction of the immunization rate to 0.31 % (95 % CI 0.17, 0.56) by ante- and postnatal RhIg [18].
Alloimmunization in Pregnancy
2020, Immunologic Concepts in Transfusion MedicineHaemolytic Disease of the Fetus and Newborn
2019, Fetal Medicine: Basic Science and Clinical Practice