Elsevier

Transfusion Medicine Reviews

Volume 2, Issue 3, September 1988, Pages 129-150
Transfusion Medicine Reviews

The Prevention of Rh Immunization

https://doi.org/10.1016/S0887-7963(88)70039-5Get rights and content

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  • Cited by (132)

    • Missed anti-D immune globulin administration to postpartum patients in 2 health systems: an unrecognized patient safety risk

      2022, AJOG Global Reports
      Citation Excerpt :

      Anti-D immune globulin (RHIG), a human plasma derivative, can prevent alloimmunization in Rh-negative patients who deliver Rh-positive infants. Despite an unclear mechanism, postpartum anti-D prophylaxis is highly effective and reduces the rate of alloimmunization to only 1% to 2%.3 With an additional prophylactic administration at 28 weeks’ gestation, this rate can be lowered even further to 0.1%.4

    • RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates

      2020, Transfusion and Apheresis Science
      Citation Excerpt :

      RhIg is not indicated in women who are alloimmunized already, since RhIg is not able to revoke any previous immunization [6]. Retrospective cohort-studies with historical control groups revealed that routine antenatal anti-D prophylaxis at the end of the 2nd or at the beginning of the 3rd trimenon is able to reduce the anti-D immunization rate after pregnancy of a RhD negative woman with an RhD positive child from 0.8 to 1.5 % to about 0.1 – 0.2 % [1,17]. A meta-analysis adjusted for differences in study design and quality showed a reduction of the immunization rate to 0.31 % (95 % CI 0.17, 0.56) by ante- and postnatal RhIg [18].

    • Alloimmunization in Pregnancy

      2020, Immunologic Concepts in Transfusion Medicine
    • Haemolytic Disease of the Fetus and Newborn

      2019, Fetal Medicine: Basic Science and Clinical Practice
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