Elsevier

Nutrition Research

Volume 19, Issue 10, October 1999, Pages 1437-1446
Nutrition Research

Human study
Tolerance of large doses of vitamin a given to mothers and their babies shortly after delivery

https://doi.org/10.1016/S0271-5317(99)00101-3Get rights and content

Abstract

Objective: To assess the acute side effects of a 400,000 IU oral dose of vitamin A given to a newly delivered mother and a 50,000 IU oral dose of vitamin A given at the same time to her baby.

Design: Randomised double blind placebo controlled clinical trial, with follow up one to two days after dosing.

Setting: Urban maternity centres in Harare, the capital of Zimbabwe.

Subjects: 839 newly delivered mothers and babies.

Outcome measures: Symptoms and signs possibly attributable to acute vitamin A toxicity in the baby (especially bulging fontanelle) or mother (headache, blurred vision, nausea, vomiting).

Results: 788 (94%) of 839 recruits were assessed. Vitamin A and control groups were similar in baseline characteristics. The incidence of reported side effects was low and comparable to that found previously. Two mothers in each group spontaneously reported bulging fontanelles in their babies. One of these babies (in the placebo group) was reported to have been vomiting. The rate of incident bulging fontanelles found on examination was 1.5% and 1.0% in the treatment and control groups respectively (odds ratio 1.48, 95% confidence limits 0.35 and 7.19, p=0.5). Only one baby (in the vitamin A group) of the eleven who were found to have bulging fontanelles on examination had a symptom (vomiting) possibly attributable to raised intracranial pressure. Maternal symptoms did not differ between groups.

Conclusion: These large doses of vitamin A are well tolerated by newly delivered mothers and babies.

References (36)

  • RW Nduati et al.

    Human immunodeficiency virus type 1-infected cells in breast milk: association with immunosuppression and vitamin A deficiency

    J Infect Dis

    (1995)
  • T Agoestina et al.

    Safety of one 52-mmol (50,000 IU) oral dose of vitamin A administered to neonates

    Bull WHO

    (1994)
  • KP West et al.

    Tolerance of young infants to a single, large dose of vitamin A: a randomized community trial in Nepal

    Bull WHO

    (1992)
  • J Marie et al.

    Acute hypervitaminosis A of the infant

    Its clinical manifestation with benign acute hydrocephalus and pronounced bulge of the fontanel; a clinical and biologic study

    Am J Dis Child

    (1953)
  • NJ Siegel et al.

    Chronic hypervitaminosis A with intracranial hypertension and low cerebrospinal fluid concentration of protein

    Clin Pediatr

    (1972)
  • CP Mahoney et al.

    Chronic vitamin A intoxication in infants fed chicken liver

    Pediatrics

    (1980)
  • M Gangemi et al.

    Intracranial hypertension due to acute vitamin A intoxication

    Acta Neurol

    (1985)
  • B Persson et al.

    Chronic vitamin A intoxication during the first half year of life

    Acta Paediatr Scand

    (1965)
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