Microbiology confirmatory tests for blood donors
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Cited by (15)
Evaluation of serological transfusion-transmitted viral diseases and mutliplex nucleic acid testing in malaysian blood donors
2013, Transfusion and Apheresis ScienceCitation Excerpt :We found that the majority of discrepant reactive results reacted with anti-HCV antibodies but were negative by NAT and confirmatory testing (INNO-LIA test). The possible explanations for “False Reactive” results via Serological false positive reactivity might be due to either cross-reactivity or contaminants in coating antigens, or to levels of DNA / RNA concentrations in specimens tested that were below detectable limits by molecular test [6,19,20]. Some patients with discrepant serology vs. NAT results might be “biological false positives” who have cleared their infections while others are “analytic” false positives that, in the absence of past infection, have positive serology due to cross-reactivity or other factors that reduce the specificity of the assay [21,22].
Can we improve the management of blood donors with nonspecific reactivity in viral screening and confirmatory assays?
2005, Transfusion Medicine ReviewsDiagnosis of HIV infection and laboratory monitoring of its therapy
2001, Journal of Clinical VirologyComparison between screening and confirmatory serological assays in blood donors in a Region of South Italy
2014, Journal of Clinical Laboratory AnalysisEffectiveness of confidential unit exclusion in screening blood donors of the regional blood bank in Londrina, Paraná State
2011, Revista Brasileira de Hematologia e Hemoterapia