Short communicationInduction of the PAC1-R (PACAP-type I receptor) gene by p53 and Zac
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Acknowledgements
This work was supported by grants from the DFG (Sp 386/3-1) and the Centre Nationale de la Recherche Scientifique.
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Cited by (39)
Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression
2018, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Our results are consistent with this conclusion, and it is also confirmed that such regulation is achieved by Zac1's direct activation of GPR39. The genome-wide expression profiling in the neural stem cells has found that the G-protein-coupled receptor PAC1 [18,54] is a Zac1's target gene, and this study further confirms that the member of the G protein-coupled receptor family, GPR39, is one of the direct target genes for Zac1. After the combination of our previous findings and the results of this study, we believe that the functional discrepancy of Pax7 and Pax3 in myogenic differentiation should be attributed to that only Pax7 could activate the Zac1/GPR39 system, making myogenic cells more likely to differentiate and form type II muscle fibers.
Early changes in pituitary adenylate cyclase-activating peptide, vasoactive intestinal peptide and related receptors expression in retina of streptozotocin-induced diabetic rats
2012, PeptidesCitation Excerpt :Recently, Onoue et al. [33] demonstrated that PACAP attenuates STZ-induced apoptotic death of RIN-m5F cells (a rat insulinoma beta cell line) through a decrease of proapoptotic factors such as Bax and by inducing a 2.3-fold enhancement of Bcl-2 mRNA expression. It has also been demonstrated that after focal cerebral ischemia, the p53 is up-regulated, and the p53 protein has been demonstrated to regulate the PAC1 receptor gene, which, in the presence of PACAP38, can attenuate the damages of ischemia [8,17]. Recently, Mester et al. [30] showed that PACAP is protective against oxidative stress in human retinal pigment epithelial cells adding an additional piece of evidence for the retinoprotective effects of this peptide.
ZAC1 target genes and pituitary tumorigenesis
2010, Molecular and Cellular EndocrinologyDistribution and functional characterization of pituitary adenylate cyclase-activating polypeptide receptors in the brain of non-human primates
2009, NeuroscienceCitation Excerpt :Interestingly, PACAP38 can cross the blood–brain barrier by means of a peptide transport system (Banks et al., 1996; Mizushima et al., 1999), and it has been shown that PACAP, given intravenously, can protect neuronal damage induced by ischemia even if the peptide is administered 4 h after medial cerebral artery occlusion (Reglodi et al., 2000). Moreover, cerebral ischemia enhances the expression of the PACAP (Stumm et al., 2007) and PAC1-R genes (Gillardon et al., 1998; Ciani et al., 1999). Consistent with these observations, recent studies conducted on PACAP knock-out mice have revealed that endogenous PACAP, acting through the PAC1 receptor, exerts a neuroprotective effect after stroke (Chen et al., 2006; Ohtaki et al., 2006).