Clinical studyImmune thrombocytopenia in pregnancy: autoimmune and alloimmune☆
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Cited by (50)
Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers
2015, BloodCitation Excerpt :In contrast, Meschengieser and Lazzari11 described an ITP patient who gave birth to a thrombocytopenic preterm infant who was breastfed from day 5 without apparent adverse effects on his platelet count. In his review, Bussel12 mentioned a patient with persistent thrombocytopenia who recovered only when breastfeeding was avoided. In our view, breastfeeding should not be discouraged, but when low platelet counts persist, discontinuing breastfeeding is a viable solution.
Platelets and plateletalloantigens: Lessons from human patients and animal models of fetal and neonatal alloimmune thrombocytopenia
2015, Genes and DiseasesCitation Excerpt :It is currently unknown whether this novel Fc-independent platelet clearance pathway also occurs in fetuses and contributes to FNAIT. Expecting mothers with pre-existing ITP have been less well studied and as such the effect of the disease on neonates is controversial.91,92 Neonatal thrombocytopenia in mothers with ITP cannot be predicted by history or platelet count, however an affected older sibling is a reliable risk factor in subsequent pregnancies.93
Neonatal thrombocytopenia
2008, Seminars in Fetal and Neonatal MedicineCitation Excerpt :Around 10% of infants of affected mothers develop thrombocytopenia. It is a less common cause of NT than NAITP, affecting 1–5 in 10,000 pregnancies.42,43 Thrombocytopenia is usually mild and ICH is rare (<1% of at-risk babies).
Thrombocytopenia in the Neonate
2008, Blood ReviewsCitation Excerpt :Transplacental passage of maternal auto-antibodies in this setting is much less of a clinical problem than NAIT. Thrombocytopenia only occurs in ∼10% of neonates whose mothers have autoantibodies and the incidence of ICH is 1% or less.47 Therefore fetal blood sampling or cesarean delivery in mothers with autoimmune thrombocytopenia is not normally necessary irrespective of the platelet count during pregnancy.44,48
Thrombocytopenia in the newborn
2007, Platelets
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Paper presented by invitation at the first International Conference on Experimental and Clinical Reproductive Immunobiology, Charlottesville, VA, USA, October, 1997.
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