Bacterial meningitis in the newborn: A prospective study of mortality and morbidity

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Neonatal bacterial meningitis is a serious disease around the world, with the incidence changing little in the past 30 years. Group B streptococci, Esherichia coli, and Klebsiella pneumoniae are common causative organisms and lumbar puncture remains the definitive method of diagnosis. The mortality rate has declined in industrialized countries over the years, from almost 50% in the 1970s to less than 10% in 1997. However, neurological sequelae are still frequently observed despite major changes in treatment. Preliminary analysis of our own data from a prospective study of cases in the United Kingdom suggests that treatment with third generation cephalosporins is related to a decrease in mortality but not morbidity.

References (26)

  • UnhanandM et al.

    Gram-negative enteric bacillary meningitis: a twenty-one year experience

    J Pediatr

    (1993)
  • OdioCM

    Cefotaxime for treatment of neonatal sepsis and meningitis

    Diagn Microbiol Infect Dis

    (1995)
  • WeissMG et al.

    Meningitis in premature infants with respiratory distress: role of admission lumbar puncture

    J Pediatr

    (1991)
  • SanghviKP et al.

    Neonatal bacterial sepsis in a neonatal intensive care unit: a 5 year analysis

    J Paediatr Child Health

    (1996)
  • ChotpitayasunondhT

    Bacterial meningitis in children: etiology and clinical features, an 11-year review of 618 cases

    Southeast Asian J Trop Med Public Health

    (1994)
  • AdhikariM et al.

    A 4-year study of neonatal meningitis: clinical and microbiological findings

    J Trop Pediatr

    (1995)
  • SchaadUB

    Etiology and management of neonatal bacterial meningitis

    Antibiot Chemother

    (1992)
  • SynnottMB et al.

    Neonatal meningitis in England and Wales: a review of routine national data

    Arch Dis Child

    (1994)
  • De LouvoisJ et al.

    Infantile meningitis in England and Wales: a two year study

    Arch Dis Child

    (1991)
  • HoltDE et al.

    Bacterial meningitis in the newborn: a prospective study of mortality and morbidity

  • FortnumHM et al.

    Epidemiology of bacterial meningitis

    Arch Dis Child

    (1993)
  • de LouvoisJ

    Acute bacterial meningitis in the newborn

    J Antimicrob Chemother

    (1994)
  • ChotpitayasunodhT

    Bacterial meningitis in children: Etiology and clinical features. An 11-year review of 618 cases

    Southeast Asian J Trop Med Pub Health

    (1994)
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