Platelet disorders in newborn infants: Diagnosis and management
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Cited by (59)
Disorders of Coagulation in the Neonate
2018, Hematology: Basic Principles and PracticeDisorders of Coagulation in the Neonate
2017, Hematology: Basic Principles and PracticePlatelet Function in the Newborn
2013, PlateletsPlatelet Function in the Newborn
2012, Platelets, Third EditionA founder mutation in the MPL gene causes congenital amegakaryocytic thrombocytopenia (CAMT) in the Ashkenazi Jewish population
2011, Blood Cells, Molecules, and DiseasesCitation Excerpt :We therefore calculate that the presence of all six MPL-associated polymorphisms present on the c.79 + 2T > A-bearing allele is a rare event and occurs in at most 0.4% of individuals of the AJ descent who do not carry the c.79 + 2T > A mutation. Thrombocytopenia is a common clinical problem observed in neonates and can be due to placental insufficiency, a congenital infection or an autoimmune or alloimmune response [28–31]. CAMT, which is caused by the homozygous or compound heterozygous presence of mutations in the thrombopoietin receptor-encoding gene, MPL, is viewed as a rare cause of thrombocytopenia in a neonate.
Advances and Controversies in Neonatal ICU Platelet Transfusion Practice
2008, Advances in PediatricsCitation Excerpt :A sensitivity analysis (Fig. 4 and Table 4) suggests that the platelet transfusions themselves likely were responsible for some fraction of the increasing mortality rate. Establishing NICU transfusion guidelines has been advocated as a way of improving practice and reducing unnecessary transfusions [47–54]. In 2002, Intermountain Healthcare, a not-for-profit healthcare organization in the Western United States, established and implemented a written set of NICU transfusion guidelines.