Clinical PracticeWhy monitor peak vancomycin concentrations?
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Cited by (93)
Dose optimization and target attainment of vancomycin in children
2024, Clinical BiochemistryVancomycin pharmacokinetics in patients with severe burn injuries
2010, BurnsCitation Excerpt :There has been considerable controversy in the literature over the utility of vancomycin serum concentration monitoring due to the lack of clinical trials relating specific vancomycin serum concentrations to clinical outcome [1–3,20,27]. Monitoring of peak serum concentrations now appears to be of little value, due to the time-dependent antimicrobial activity of vancomycin, the lack of a clear correlation between specific serum concentrations and toxicity, as well as, significant practical issues involved in obtaining a comparable and reliable peak concentration due to the multicompartment pharmacokinetics of the drug [3,4,28], the difficulty of which has been demonstrated in the Australasian setting [29]. Trough vancomycin concentrations remain of value to clinicians; in part due to the finding that vancomycin exerts maximal antibacterial effects at concentrations of 4–5 times the MIC [19,30,31].
Antibiotic resistance-What's dosing got to do with it?
2008, Critical Care Medicine