Elsevier

The Lancet

Volume 343, Issue 8908, 21 May 1994, Pages 1259-1260
The Lancet

Short reports
Can expression of CD45RO, a T-cell surface molecule, be used to detect congenital infection?

https://doi.org/10.1016/S0140-6736(94)92153-9Get rights and content

Abstract

Exclusion or confirmation of congenital infection can be difficult in newborn infants. The presence of an infective organism in a fetus leads to activation of fetal T lymphocytes. We have examined expression of isoforms of a T-cell surface molecule, CD45RO, in 119 infants, 8 of whom had an intrauterine infection diagnosed antenatally. CD45RO was expressed on fewer than 10% of T cells in control infants and on more than 17% of T cells from infants with known infection (p<0·006). This method allows screening of infants for infection by a range of organisms as a cause of their infection.

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