Letters to the EditorINTRAVENOUS EPIDERMAL GROWTH FACTOR/UROGASTRONE INCREASES SMALL-INTESTINAL CELL PROLIFERATION IN CONGENITAL MICROVILLOUS ATROPHY
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Cited by (107)
Growth Factors in the Gastrointestinal Tract
2012, Physiology of the Gastrointestinal Tract, Two Volume SetGrowth Factors in the Gastrointestinal Tract
2012, Physiology of the Gastrointestinal TractRecombinant Human Epidermal Growth Factor Accelerates Recovery of Mouse Small Intestinal Mucosa After Radiation Damage
2008, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :Previous animal studies have indicated that rhEGF induces hyperplasia of the small-bowel mucosal layer (15–17). In a neonate with congenital microvillus atrophy, EGF was been found to stimulate epithelial proliferation, and the great potential for the therapeutic use of EGF has been demonstrated in an infant with necrotizing enterocolitis (18–20). Our results showed increases in mucosal regeneration after irradiation, as well as decreased inflammatory reactions, in rhEGF-treated mice compared with radiation-treated controls, and mice treated with high doses of rhEGF reacquired a nearly normal mucosal appearance.
A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome
2005, Journal of Pediatric SurgeryCitation Excerpt :Based on these observations, we have studied the effects of enterally administered EGF in an animal model of severe SBS and noted significant improvements in weight gain, nutrient absorption, and intestinal permeability [21]. From these findings and previous reports of pilot studies using intravenous EGF [22,23], we undertook the present study examining the effects of enterally administered EGF on nutrient absorption in human pediatric patients with severe SBS. We hypothesized that EGF treatment would improve nutrient absorption and thus increase the tolerance of feeds given enterally.
Effect of epidermal growth factor infusion on fetal rabbit intrauterine growth retardation and small intestinal development
2004, Journal of Pediatric Surgery