Elsevier

The Lancet

Volume 356, Issue 9236, 30 September 2000, Pages 1162-1163
The Lancet

Research Letters
Reduced development of cerebral cortex in extremely preterm infants

https://doi.org/10.1016/S0140-6736(00)02761-6Get rights and content

Summary

Most growth in cortical connections and complexity occurs after 25 weeks. The cerebral cortex of extremely preterm infants when imaged at gestational age 38–42 weeks had less cortical surface area and was less complex than in normal infants born around term (p<0·0148 and p<0·0002, respectively), despite similar term-corrected cerebral tissue volumes. Since deficits acquired during critical periods of brain development may be permanent, these results suggest a neural substrate for the neurocognitive impairment that is frequent among such preterm infants.

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