Umbilical cord blood interleukin-6 levels and neonatal morbidity
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Cited by (63)
Advances in cerebral palsy biomarkers
2021, Advances in Clinical ChemistryCitation Excerpt :Infants with neonatal encephalopathy were reported to have elevated cerebrospinal fluid and plasma cytokine levels [169], including those who later developed poor neurological outcomes [170]. Further studies have been shown to find elevated umbilical cord blood IL-6 levels in infants with perinatal asphyxia or neonatal encephalopathy [171,172]. Contrastingly, umbilical cord blood IL-8, IL-1β, and TNF-α levels in preterm infants did not yield significant association with subsequent CP [173].
Preterm Intraventricular Hemorrhage/Posthemorrhagic Hydrocephalus
2018, Volpe's Neurology of the NewbornFetal and early neonatal interleukin-6 response
2015, CytokineAssociation of antenatal steroid use with cord blood immune biomarkers in preterm births
2011, Early Human DevelopmentCitation Excerpt :A growing body of literature suggests an association between cytokine levels in the perinatal period and neonatal outcomes [8–13]. Elevated cord blood IL-6 levels have been associated with an increased risk for periventricular leukomalacia, intraventricular hemorrhage, and necrotizing enterocolitis in infants born at less than 32 weeks gestation [8–10,13]. Prenatal exposure to maternal infection has been shown to affect the levels of pro-inflammatory and neurotrophic cytokines in the fetus [14,15].
A multicenter study on the clinical outcome of chorioamnionitis in preterm infants
2009, American Journal of Obstetrics and GynecologyInterleukin-6 Polymorphism is Associated with Chorioamnionitis and Neonatal Infections in Preterm Infants
2008, Journal of Pediatrics