Early increase in endothelin-1 in tracheal aspirates of preterm infants: Correlation with bronchopulmonary dysplasia☆,☆☆,★
Section snippets
Patient Groups
Preterm infants born at 28 weeks of gestation or sooner who required mechanical ventilation for RDS and who had been admitted to the neonatal intensive care unit at the University Medical Center at Stony Brook were recruited for this study. Excluded from the study were infants with sepsis verified by positive blood culture results at birth, with perinatal asphyxia, with severe persistent pulmonary hypertension, and with major congenital anomalies. Infants who remained oxygen dependent at 36
Results
Thirty-four infants born at 28 weeks' gestation or sooner and with RDS were entered into the study; BPD developed in half of them. Clinical characteristics of the two groups (non-BPD and BPD) were similar for gestational age, birth weight, maternal antenatal steroid therapy, duration of rupture of membranes or histologic evidence of chorioamnionitis or both, rate of cesarean delivery, and surfactant replacement therapy. There were significantly more boys (59% vs 18%) and a higher mean initial
Discussion
Most mammalian cells and tissues express ET-1; however, they are present in the largest amounts in the lungs, particularly in the trachea, bronchiolar smooth muscle and epithelia, pulmonary tissues, bronchoalveolar space, and pulmonary circulation. In adults, ET-1 has been implicated as a mechanism of injury in diseases involving abnormal vascular reactivity and hypoxia-ischemia, such as hypertension, myocardial and cerebral infarction, sepsis syndromes, and other vasculopathies.19 A role for
Acknowledgements
We thank the nurses in the neonatal unit for their continuing support. A special thank-you is extended to Dr. Leonard I. Kleinman for his assistance with statistics and his critical review of the manuscript.
References (35)
- et al.
Endothelin, a novel vasoconstrictor peptide, as potent bronchoconstrictor
Eur J Pharmacol
(1988) - et al.
Circulating endothelin-1 concentrations in acute respiratory failure
Chest
(1993) - et al.
Elevated immunoreactive endothelin-1 levels in newborns with persistent pulmonary hypertension
J Pediatr
(1993) - et al.
Regulation of endothelin-1 synthesis in cultured guinea pig airway epithelial cells by various cytokines
Biochem Biophys Res Commun
(1992) - et al.
Endothelin-1 stimulates arachidonate 15-lipoxygenase activity and oxygen radical formation in the rat distal lung
Biochem Biophys Res Commun
(1990) - et al.
Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea pig
Biochem Biophys Res Commun
(1989) - et al.
A novel potent vasoconstrictor peptide produced by vascular endothelial cells
Nature
(1988) - et al.
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
N Engl J Med
(1993) - et al.
Plasma endothelin-1 in the neonatal respiratory distress syndrome
Ann Chir Gynaecol
(1993) - et al.
Plasma endothelin-1 like immunoreactivity levels in neonates
Eur J Pediatr
(1992)
Plasma endothelin-1 concentrations at different ages during infancy and childhood
Acta Pediatr
Endothelin1-21 plasma concentrations on days 1 and 4 of life in healthy and ill preterm neonates
Biol Neonate
Chronic lung disease
Pulmonary hypertension in severe acute respiratory failure
N Engl J Med
Association of pulmonary inflammation and increased microvascular permeability during the development of BPD: a sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates
Pediatrics
Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease
Arch Dis Child
Increased activity of interleukin-6 but not tumor necrosis factor-α in lung lavage of premature infants is associated with the development of bronchopulmonary dysplasia
Pediatr Res
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2012, Journal of PediatricsCitation Excerpt :CT-proET-1, however, was not predictive of BPD after adjusting for GA. An early increase in endothelin-1 was a prognostic factor for BPD when endothelin-1 in tracheal aspirate was measured on day 7 of life.9 In our study, plasma CT-proET-1 concentrations were measured on day 3 of life, which may reduce prognostic power compared with measurement on day 7.
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From the Department of Pediatrics (Division of Neonatal Medicine), State University of New York at Stony Brook, and St. Mary's Hospital, Leonardtown, Maryland.
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Reprint requests: Lance A. Parton, MD, Department of Pediatrics, State University of New York at Stony Brook, Stony Brook, NY 11794-8111.
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0022-3476/98/$5.00 + 0 9/21/88985