Growth and body composition in infants with bronchopulmonary dysplasia up to 3 months corrected age: A randomized trial of a high-energy nutrient-enriched formula fed after hospital discharge☆,☆☆,★,★★
Section snippets
Patients and Methods
Infants were recruited from the Neonatal Intensive Care Units at The Children’s Hospital, Hamilton Health Sciences Corporation and St. Joseph’s Hospital, Hamilton, Ontario, between January 1991 and November 1994. The study was approved by the Research Project Advisory Committees at both hospitals. Eligible infants weighed <1500 g at birth and were appropriate for gestational age, had BPD, were formula fed by parental choice, had no major congenital anomalies, and had not undergone
Results
Thirty infants were randomized to each of the 2 nutritional interventions (SF, 13 male infants; EF, 18 male infants). Four infants in the EF group dropped out after term age because of unfounded lactose intolerance, parental request, recurrent excoriated buttocks, or death from respiratory complications. The infants in the SF and EF groups were similar in birth weight (866 ± 169 g), gestational age (26.0 ± 1.5 weeks), days ventilated (38 ± 18), total cumulative steroid dose (about 6.2 mg/kg
Discussion
This randomized blinded study documented accelerated growth in infants with BPD in response to a protein-, mineral-, and energy-enriched formula provided after discharge from hospital. The period of most improved growth was from approximately 37 weeks’ PMA to 1 month CA. The standard term infant formulas commonly used after discharge, even if supplemented with energy, will not support the growth potential that was observed in the infants who were fed EF.
Enhanced growth with feeding of an
Acknowledgements
We are grateful to the families and the infants who participated in this study and to Michelle Whelan, RN, for her skill in acquiring measurements of infants. We are also appreciative of the staff of the Growth and Development Clinic at the Children’s Hospital for assisting in the timely follow-up of the infants in this study. Individual group data for all outcomes measured are available from the authors on request.
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Cited by (0)
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From the Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
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Funded by a grant from the Ontario Ministry of Health, with formula manufactured to investigators’ specifications and donated by Wyeth-Ayerst Int., Radnor, Pennsylvania.
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Reprint requests: Stephanie Atkinson, PhD, Professor, Department of Pediatrics, HSC 3V42, McMaster University, 1200 Main St. West, Hamilton, Ontario, Canada L8N 3Z5.
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0022-3476/98/$5.00 + 0 9/21/89554