Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection☆,☆☆,★
Section snippets
Study population
The study population consisted of children born between 1980 and December 1995, who were identified by newborn screening for congenital CMV infection at two hospitals in Birmingham, Ala. 14, 15 Congenital CMV infection was identified by isolation of virus in urine or saliva in the first or second week of life. 16, 17, 18 These children were assessed and their medical records were systematically reviewed by study personnel to determine whether any of the following symptoms were observed in the
RESULTS
There were 584 children in the study population who had audiologic evaluations to assess SNHL. The children were divided into three groups: 307 children with congenital CMV infection, 76 uninfected siblings of children with asymptomatic congenital infection, and 201 randomly selected control children. Characteristics for each group of children are shown in Table I. The CMV-negative group was more likely to be black, have Medicaid or no insurance, and receive prenatal care at the health
DISCUSSION
Our study found a prevalence of SNHL of 7.2% (95% CI, 4.5% to 10.6%) for children with asymptomatic congenital CMV infection. Approximately half of the children with SNHL had bilateral hearing loss. The severity of loss ranged from mild high-frequency loss to profound loss, with further deterioration of hearing occurring in 50% of the children with SNHL. Late-onset hearing loss occurred in about 20% of the children with SNHL. Neither the siblings nor the children whose test results were
References (35)
- et al.
Congenital and postnatally acquired cytomegalovirus infections: long-term follow-up
J Pediatr
(1984) - et al.
Congenital cytomegalovirus infection and neonatal auditory screening
J Pediatr
(1993) Epidemiology of hearing loss and aetiological diagnosis of hearing impairment in childhood
Int J Pediatr Otorhinolaryngol
(1983)- et al.
Epidemiologic patterns in childhood hearing loss: a review
Int J Pediatr Otorhinolaryngol
(1989) Infectious Diseases Society of America and Centers for Disease Control: summary of a workshop on surveillance for congenital cytomegalovirus disease
Rev Infect Dis
(1991)- et al.
Inapparent congenital cytomegalovirus infection with elevated cord IgM levels: causal relationship with auditory and mental deficiency
N Engl J Med
(1974) - et al.
School failure and deafness after “silent” congenital cytomegalovirus infection
N Engl J Med
(1976) - et al.
The outcome in children with congenital cytomegalovirus infection: a longitudinal follow-up study
Am J Dis Child
(1982) - et al.
Congenital cytomegalovirus infection
Arch Dis Child
(1984) - et al.
Neurodevelopmental assessment after congenital cytomegalovirus infection
Arch Dis Child
(1986)
Intellectual development in school-aged children with asymptomatic congenital cytomegalovirus infection
Pediatrics
Asymptomatic congenital cytomegalovirus infection
Am J Dis Child
Progressive hearing loss in infants with asymptomatic congenital cytomegalovirus infection
Pediatrics
The outcome of congenital cytomegalovirus infection in relation to maternal antibody status
N Engl J Med
Auditory and visual defects resulting from symptomatic and subclinical congenital cytomegaloviral and toxoplasma infections
Pediatrics
Progressive hearing impairment in children with congenital cytomegalovirus infection
J Speech Hear Disord
Primary cytomegalovirus infection in pregnancy: incidence, transmission to fetus, and clinical outcome
JAMA
Cited by (458)
Usefulness of Yoga in the management of tinnitus during COVID-19: A narrative review
2024, Journal of Ayurveda and Integrative MedicineEndolymphatic hydrops and fluctuating hearing loss in a patient with congenital cytomegalovirus infection
2023, Otolaryngology Case ReportsAnalysis of hearing prognosis risk factors in pediatric unilateral sudden sensorineural hearing loss
2023, American Journal of Otolaryngology - Head and Neck Medicine and SurgeryThe cost-effectiveness of targeted screening for congenital cytomegalovirus in newborns compared to clinical diagnosis in the US
2023, International Journal of Pediatric Otorhinolaryngology
- ☆
Supported in part by a research grant (5 P01 HD 10699) from the National Institute of Child Health and Human Development, a research grant (5 R01 DC 02139) from the National Institute on Deafness and Other Communication Disorders, and a research grant (5 M01 RR 00032) from the General Clinical Research Center, National Institutes of Health, the Deafness Research Foundation, and the Civitan International Research Center.
- ☆☆
Reprint requests: Karen B. Fowler, DrPH, Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Ave. South, Suite 752, Birmingham, AL 35233.
- ★
0022-3476/97/$5.00 + 0 9/21/78377