Ultrasound measurement of gastric emptying time in patients with cystic fibrosis and effect of ranitidine on delayed gastric emptying☆,☆☆,★
Section snippets
METHODS
In 29 patients with CF (16 girls; median age, 10.2 years; range, 5 to 17 years), gastric emptying time of a solid-liquid mixed meal was measured by ultrasonography of the stomach. In all patients, the diagnosis of CF had been established through a previous positive sweat test result (sweat chloride determination, >70 mmol/L) and the presence of typical clinical symptoms and signs. Patients entering into the study had not exhibited severe clinical features of intestinal dysmotility, such as
RESULTS
Gastric emptying time was significantly delayed in patients with CF in comparison with control subjects; distention of the antral area (percentage of increase compared with baseline value) was markedly higher in patients with CF both 60 and 90 minutes after feeding, in comparison with control subjects (Table I). Twenty-six patients with CF had a gastric emptying time beyond the range of values measured in the control subjects; these patients were randomly allocated to receive either cisapride
DISCUSSION
This study shows that gastric motor abnormalities such as delayed gastric emptying and exaggerated postfeeding antral distention can be found in a high proportion of patients with CF. Gastric motility was assessed through real-time ultrasonography, a recently introduced and validated tool for studying the gastric motor profile.11, 13, 14 Previous reports on patients with CF had shown a normal gastric emptying time of liquid meals.15, 16 Gastric emptying time is commonly believed to be
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Cited by (64)
Review of paediatric gastrointestinal physiology relevant to the absorption of orally administered medicines
2022, Advanced Drug Delivery ReviewsCitation Excerpt :Since dosage forms administered to paediatric patients, mainly represented by liquids (syrups, suspensions), single or multiple units, are often co-administered with liquids or semi-solid meals (yoghurt, apple sauce etc.), available data sets on gastric emptying patterns may provide an estimate of the gastric residence time of these formulations. The most commonly applied methods were ultrasound [350,404,417–423,425,426,428,430–432,434,435,522,528,531,540,541,545–548,565–577] and the 13CO2 breath test [331,406,437,578–592]. Real-time ultrasound is a non-invasive and non-radioactive technique to assess the gastric emptying rate of ingested test meals [593,594].
Gastroesophageal Reflux
2020, Pediatric Gastrointestinal and Liver Disease, Sixth EditionPreliminary report of the <sup>13</sup>C-mixed triglyceride breath test to assess timing of pancreatic enzyme replacement therapy in children with cystic fibrosis
2016, Journal of Cystic FibrosisCitation Excerpt :The inter-individual variation in PCDR observed may be explained by a number of factors such as differing levels of gastric and lingual lipase observed in CF [20], variation in residual pancreatic function [21], and variation in pancreatic bicarbonate secretion which can result in duodenal hyperacidity [22] and subsequently impaired acid neutralization [23] and fat digestion. Our conflicting gastric emptying results are consistent with literature reports of accelerated [9], normal [10] and delayed [11] solid or liquid gastric emptying in CF subjects. Few studies have assessed the gastric emptying rate of solid meals in CF and display conflicting results of accelerated [9] and delayed [11] emptying compared to controls.
Gastric emptying and gastro-oesophageal reflux in children with cystic fibrosis
2016, Journal of Cystic FibrosisCitation Excerpt :This could be expected as we defined DGE as t1/2-GE > P90 and RGE as t1/2-GE < P10 according to normal values established in healthy children (submitted). DGE for solids, solid/liquid meal and liquids was reported respectively in 72.7%, 89.7% and 33.3% of children with CF [8,24,25]. DGE for solids and liquids was found respectively between 5.8% and 97.0% and between 0% and 67.0% of adults with CF [7,26–29].
Reduced levels of active GLP-1 in patients with cystic fibrosis with and without diabetes mellitus
2012, Journal of Cystic FibrosisCitation Excerpt :In contrast, we were not able to see effects of pancreatic enzyme supplementation on GLP-1 in our study. Reports on gastric emptying rate in CF are also conflicting and both increased and delayed gastric emptying have been suggested in this group of patients [28-32]. Together with gastric dysmobility and malnutrition often observed in these patients it is tempting to speculate on the impact of incretins in this group of patients.
Erythromycin improves gastric emptying half-time in adult cystic fibrosis patients with gastroparesis
2009, Journal of Cystic Fibrosis
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From the Department of Pediatrics, University of Naples “Federico II,” Naples, Italy
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Reprint requests: Salvatore Cucchiara, MD, Department of Pediatrics, Gastrointestinal Motility and Endoscopy Unit, University of Naples “Federico II,” Via S.Pansini 5, 80131 Napoli, Italy.
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0022-3476/96/$5.00 + 0 9/20/71607