Granulocyte colony-stimulating factor as a marker for bacterial infection in neonates☆,☆☆,★,★★
Section snippets
Study population
In this prospective study we sought to enroll all babies who were examined for bacterial infection and who were in the University of New Mexico Hospital newborn intensive care unit from October 1993 through February 1995. The decision to examine an infant for sepsis was made with the use of standard criteria such as premature or prolonged rupture of membranes, respiratory distress, hypotension, temperature instability, and problems with glucose regulation. Babies were enrolled once informed
RESULTS
Of 620 eligible infants, 171 infants were enrolled. Eligible infants not enrolled were those whose parents chose not to participate or those admitted when study personnel were not available. Fifteen enrolled infants were excluded because insufficient blood was collected. The remaining 156 enrolled infants underwent 176 evaluations for sepsis. Fourteen babies were evaluated on more than one occasion because they had prolonged hospital stays and several evaluations for sepsis. Thus the same baby
DISCUSSION
The lack of specificity of careful clinical and laboratory examination in detecting neonatal sepsis presents a daunting problem to clinicians. Because undiagnosed sepsis can lead to rapid deterioration and death, and because isolation of the causative organism from blood samples is insensitive and can take up to 48 hours, antibiotics are administered to infants on the basis of nonspecific findings. As a result, considerable overhospitalization, overuse of antibiotics, and other inefficiencies
Acknowledgements
We thank Dr. C. Qualls for assistance with statistical analysis and Dr. LuAnn Papile for critical review. We also thank Connie Backstrom, Lisa Merker, and Carol Hartenberger, working with the Clinical Research Center, for their tremendous assistance in recruiting infants, maintaining patient data, and collecting blood samples.
References (15)
- et al.
Levels of serum granulocyte colonystimulating factor in patients with infections
Blood
(1990) - et al.
Serum concentrations of granulocyte colony-stimulating factor in healthy term and preterm neonates and in those with various diseases including bacterial infections
Blood
(1993) - et al.
Diagnosis of neonatal bacterial infection: hematologic and pathologic findings in fatal and nonfatal cases
Pediatrics
(1979) - et al.
The peripheral white blood cell count in the diagnosis of neonatal infection
J Perinatol
(1985) - et al.
Changes in the differential white blood cell count in screening for group B streptococcal sepsis
Pediatr Infect Dis J
(1990) Leukocyte blood picture in healthy full term and premature babies during neonatal period
Arch Dis Child
(1970)- et al.
The hematology of bacterial infection in premature infants
Pediatrics
(1976)
Cited by (67)
Serum amyloid A – A prime candidate for identification of neonatal sepsis
2021, Clinical ImmunologyCitation Excerpt :However, IL-8 did turn out significantly elevated in SSG as well as ESG compared to CG at 0 h, but also at 48–72 h in all the three groups studied compared to the controls. Granulocyte colony-stimulating factor (G-CSF) has also been proposed as an early and sensitive marker of bacterial infection [25–27]. In our cohort, G-CSF does behave much like IL-6, suggesting it belongs to the fast-acting marker kinetic group.
Early and Late Infections in Newborns: Where Do We Stand? A Review
2016, Pediatrics and NeonatologyCitation Excerpt :Serial determinations improve the diagnostic accuracy and are useful for evaluating the response to treatment.47 The granulocyte colony-stimulating factor was shown to have sensitivity of 95% and negative predicting value (NPV) of 99% in detecting infection in neonates of all gestational ages when a cut-off level of 200 pg/mL was used.48 Moreover presepsin, a truncated form of soluble CD14, can be used as a reliable biomarker for LOS and treatment response in preterm infants.49
The Use of Biomarkers for Detection of Early- and Late-Onset Neonatal Sepsis
2012, Hematology, Immunology and Infectious Disease: Neonatology Questions and ControversiesDevelopmental Immunology and Role of Host Defenses in Fetal and Neonatal Susceptibility to Infection
2011, Infectious Diseases of the Fetus and Newborn InfantBacterial Sepsis and Meningitis
2011, Infectious Diseases of the Fetus and Newborn InfantDevelopmental immunology and role of host defenses in fetal and neonatal susceptibility to infection
2010, Infectious Diseases of the Fetus and Newborn: Expert Consult - Online and Print
- ☆
From the Departments of Pediatrics and Pathology, University of New Mexico School of Medicine, Albuquerque
- ☆☆
Supported by the University of New Mexico Hospital General Clinical Research Center Grant University of New Mexico, Program NCRR GCRC (NIH 5M01RR00997), and the Division of Neonatology, Department of Pediatrics, University of New Mexico.
- ★
Reprint requests: Carol Kennon, MD, Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM 87131.
- ★★
0022-3476/96/$5.00 + 0 9/20/72263