Nephrocalcinosis and nephrolithiasis in infants with congestive heart failure treated with furosemide☆,☆☆,★,★★
Section snippets
CASE REPORTS
The clinical, laboratory, and renal ultrasonographic data of the five children are presented in the Table. All patients had complex congenital heart disorders that resulted in congestive heart failure. The two children with trisomy 21 had complete atrioventricular canal, which in both was associated with pulmonary hypertension. The two children with Noonan syndrome had lesions in the pulmonary artery tree, including pulmonic stenosis. The fifth child had hypoplasia of the right side of the
DISCUSSION
Nephrocalcinosis and nephrolithiasis have been observed in up to 64% of very LBW premature infants treated with furosemide,2, 5, 7 but have not been reported in other patient populations. Of the five children observed by us, three were born at term and the other two were slightly premature. The birth weights of the latter two were greater than those of previously reported premature infants with furosemide-induced renal calcifications.1, 7 Moreover, in these two children, treatment with the loop
References (15)
- et al.
Renal calcification in preterm infants: pathophysiology and long-term sequelae
J PEDIATR
(1988) - et al.
Kidney function in very low birth weight infants with furosemide-related renal calcifications at ages 1 to 2 years
J PEDIATR
(1992) - et al.
Nephrocalcinosis
Clin Perinatol
(1992) - et al.
Metabolic and histologic investigation of the nature of nephrocalcinosis in children with hypophosphatemic rickets and in the Hyp mouse
J PEDIATR
(1992) - et al.
Cholelithiasis in premature infants treated with parenteral nutrition and furosemide
J PEDIATR
(1980) - et al.
Renal calcifications: a complication of long-term furosemide therapy in preterm infants
Pediatrics
(1982) - et al.
Renal calcification incidence in very low birth weight infants
Pediatrics
(1988)
Cited by (59)
Voltammetric oxidation and determination of loop diuretic furosemide at a multi-walled carbon nanotubes paste electrode
2012, Electrochimica ActaCitation Excerpt :Furosemide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. It is detectible in urine 36–72 h following injection [2–5]. Therefore, it analyzes directly in biological fluids.
Nephrocalcinosis and urolithiasis in children
2011, Kidney InternationalCitation Excerpt :Even short-term immobilization reduces bone mass of about 15–20% accompanied by hypercalciuria.60 Further reasons are long-term administration of furosemide, dexamethasone, or ACTH.61,62,63,64 Hypercalciuria is also found in several syndromes, either linked to the pathogenesis (Bartter's syndrome,65 Williams' syndrome66) or due to renal tubular damage (Wilsons' disease, Dent II syndrome;67,68 Table 1).
Urolithiasis in Children
2010, Pediatric UrologyUrolithiasis in children
2009, Pediatric Urology: Expert ConsultHeart failure in paediatric patients: pathophysiology and treatment. Part II
2018, Revista Colombiana de Cardiologia
- ☆
From the Divisions of Nephrology and Cardiology, and Department of Pathology, Children's Mercy Hospital, University of Missouri at Kansas City
- ☆☆
Supported in part by The Sam and Helen Kaplan Research Fund in Pediatric Nephrology.
- ★
Reprint requests: Uri Alon, MD, Section of Pediatric Nephrology, Children's Mercy Hospital, 2401 Gillham Rd., Kansas City, MO 64108.
- ★★
0022-3476/94/$3.00 + 0 9/26/55231