Administration of indomethacin for the prevention of periventricular-intraventricular hemorrhage in high-risk neonates2
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Evidence-Based Use of Indomethacin and Ibuprofen in the Neonatal Intensive Care Unit
2012, Clinics in PerinatologyCitation Excerpt :This discovery was followed by a series of short-term clinical trials in neonates.113,151,153,154 Although there was initially conflicting evidence on the effectiveness of IVH prevention, especially in infants weighing less than 1000 g,154,155 it was subsequently shown that prophylactic indomethacin (administered at <12 hours of age) was effective in reducing higher-grade IVH. In 1988, Bandstra and colleagues113 randomized almost 200 infants born at less than 1300 g to either receive 3 doses of indomethacin starting within 12 hours of birth or placebo.
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- 2
Presented in part at the American Association of Neurological Surgeons, Pediatric Subsection, Pittsburgh, Pa., December 1986, and the American Pediatric Society, Anaheim, California, April 1987.
- 1
Drs. Kennedy and Roemisch supported in part by March of Dimes Summer Fellowships 8-84-37 and 8-84-65, respectively.