Teratogenicity of cocaine in humans
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Cited by (377)
Passive Addiction and Teratogenic Effects
2018, Volpe's Neurology of the NewbornDrugs and Environmental Agents in Pregnancy and Lactation: Teratology, Epidemiology
2016, Obstetrics: Normal and Problem PregnanciesCardiovascular consequences of cocaine use
2015, Trends in Cardiovascular MedicineCitation Excerpt :It is presumed that such issues occur as a result of the vasoconstrictive effects of cocaine exposure on the maternal cardiovascular system and uteroplacental blood flow [63]. A five-fold increase in the risk of congenital malformations has been observed in cocaine-exposed pregnancies compared to cocaine-negative controls [63,64]. Recognizing cocaine as the cause of cardiovascular events is important for optimal patient management due to some of the treatment differences described below.
Recreational drugs
2015, Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment: Third EditionMOTHERISK ROUNDS: Cocaine Abuse During Pregnancy
2014, Journal of Obstetrics and Gynaecology CanadaCitation Excerpt :However, when this analysis was completed with comparison of mothers who were abusing only cocaine with the drug-free control group, the effect was no longer observed.24 Early reports by Bingol and colleagues suggested that cocaine may act as a teratogen.4 However, this study was limited in its assessment of confounding factors and had some methodological limitations.25,26
The manifestation of cocaine-induced midline destructive lesion in bone tissue and its identification in human skeletal remains
2013, Forensic Science InternationalCitation Excerpt :Although pups born to mothers administered 100 mg of cocaine daily during pregnancy did not show the same significant effects, they did generally show higher rates of intrauterine and postnatal death prior to measurement than any other group in the study and higher rates of osteopenia than pair-fed controls. Prenatal cocaine exposure is also associated with delayed ossification of paws and the skull in mice and rat pups [109] and with developmental limb and digit anomalies, cranial bone defects (including exencephaly and interparietal encephalocele, and parietal bone defects without herniation), and delayed calvarial ossification in human infants [110,111]. These findings further suggest reduced/impaired osteoblastic activity associated with cocaine use.