Prevention of symptomatic patent ductus arteriosus with a single dose of indomethacin*
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2012, The Newborn Lung: Neonatology Questions and Controversies Expert ConsultEvidence-Based Use of Indomethacin and Ibuprofen in the Neonatal Intensive Care Unit
2012, Clinics in PerinatologyCitation Excerpt :This discovery was followed by a series of short-term clinical trials in neonates.113,151,153,154 Although there was initially conflicting evidence on the effectiveness of IVH prevention, especially in infants weighing less than 1000 g,154,155 it was subsequently shown that prophylactic indomethacin (administered at <12 hours of age) was effective in reducing higher-grade IVH. In 1988, Bandstra and colleagues113 randomized almost 200 infants born at less than 1300 g to either receive 3 doses of indomethacin starting within 12 hours of birth or placebo.
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Supported by SCOR Grant HL 14214 from the National Heart, Lung, and Blood Institute, and by an American Heart Association Grant-in-Aid.
Copyright © 1987 Published by Mosby, Inc.