Brief clinical and laboratory observation
The association of rapid volume expansion and intraventricular hemorrhage in the preterm infant**

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Cited by (110)

  • Fluid Therapy: Friend or Foe?

    2020, Clinics in Perinatology
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    Adverse effects for all types of fluid boluses in neonates may occur and include volume overload, dilutional coagulopathy, hypothermia, and electrolyte abnormalities (Table 1). Observational studies suggest dose-related adverse effects of volume overload; in preterm neonates, multiple fluid boluses are associated with increased mortality28 and intraventricular hemorrhages,6 whereas lower total fluid intakes in the first week of age were correlated with decreased chronic lung disease and mortality.29,30 Whether adverse effects are precipitated by the properties of the fluid infused and/or the volume of fluids remains unclear.

  • Intraventricular Hemorrhage and White Matter Injury in the Preterm Infant

    2018, Neurology: Neonatology Questions and Controversies
  • Uses and misuses of albumin during resuscitation and in the neonatal intensive care unit

    2017, Seminars in Fetal and Neonatal Medicine
    Citation Excerpt :

    Albumin infusions are usually given as a rapid bolus. Although not directly demonstrated with albumin, the rapid infusion of colloids or blood products in preterm infants has been associated with increased risk for RDS, IVH, and death [48,49]. The risk of IVH is attributed to increased cerebral blood flow and cerebral capillary pressure to a degree sufficient to rupture the already fragile subependymal vessels [49].

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**

Presented in part at the Southern Society for Pediatric Research, New Orleans, January 26, 1980.

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