Brief clinical and laboratory observationDetection of neonatal bacteremia
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2010, Clinics in PerinatologyCitation Excerpt :However, recovery of identical organisms from replicate, independent specimens provides unequivocal evidence of a true bacteremia, and multiple negative cultures may provide stronger evidence of clearance of a previously documented bacteremia.15 Experience with manual methods, relying on development of turbidity in the culture broth, demonstrated that 96% of the cultures obtained before antibiotic administration were positive after 48 hours and 98% were positive at 72 hours.16 Automated systems for detection of bacterial growth substantially decreased the time to detection of positive cultures.17
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