Elsevier

The Journal of Pediatrics

Volume 93, Issue 4, October 1978, Pages 639-646
The Journal of Pediatrics

Closure of the patent ductus arteriosus with ligation and indomethacin: A consecutive experience

https://doi.org/10.1016/S0022-3476(78)80909-3Get rights and content

This report summarizes a consecutive experience with 59 preterm infants with clinical, radiographic, and echocardiographic findings of a large patent ductus arterious. Thirty-five infants who met defined criteria received indomethacin, and 24 infants underwent PDA ligation. Analysis of the clinical course of these infants revealed no selective indomethacin morbidity and suggests that infants undergoing ligation require more prolonged ventilator therapy with increased exposure to FiO2≥0.3. Mortality rates between ligated and pharmacologically treated groups were similar. This study documents that inhibition of prostaglandin synthesis to constrict and close the PDA in the premature infant is an effective alternative to operative closure.

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  • Cited by (0)

    Supported by HD-05292, HL-05846, HL-12373, and HL-17334.

    1

    From the Divisions of Pediatric Cardiology and Perinatal Medicine, Department of Pediatrics, University of California, San Diego and the Southwest Neonatal Center, Sunrise Hospital.

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