A prospective controlled trial of oral kanamycin in the prevention of neonatal necrotizing enterocolitis**
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Cited by (92)
Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated Diarrhea
2017, Gastroenterology Clinics of North AmericaCitation Excerpt :Several older randomized controlled trials (RCTs),53 as well as animal studies, have shown that prophylactic administration of enteral antibiotics can prevent this disease.49 Five RCTs have been conducted to evaluate the use of prophylactic enteral antibiotics (gentamicin, vancomycin, and kanamycin) for the prevention of NEC, all demonstrating significant reductions in rates of NEC,53–57 with a subsequent meta-analysis showing an almost 50% reduction in the rates of NEC and a 70% reduction in NEC-related deaths.58 However, these studies have limitations.
Necrotizing enterocolitis and preterm infant gut bacteria
2016, Seminars in Fetal and Neonatal MedicineCitation Excerpt :Aminoglycosides would be active against Gammaproteobacteria in the gut, but not suppress anaerobic bacterial populations. In the aggregate, these studies [41–44] support the use of oral aminoglycosides to prevent NEC. However, because of concerns about selecting for aminoglycoside-resistant organisms [45] and of absorption of the oral aminoglycosides from the gut (which occurs during the very earliest in life interval before the incidence of NEC increases [46]), enteral antibiotics to prevent NEC are not widely used.
Focal Bacterial Infections
2011, Infectious Diseases of the Fetus and Newborn InfantFocal bacterial infections
2010, Infectious Diseases of the Fetus and Newborn: Expert Consult - Online and PrintFocal Bacterial Infections
2006, Infectious Diseases of the Fetus and Newborn InfantClinical Pharmacology of Antibacterial Agents
2006, Infectious Diseases of the Fetus and Newborn Infant
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Supported in part by National Institutes of Health grant HD 00054-14.