The early use of continuous positive airway pressure in the treatment of idiopathic respiratory distress syndrome*

https://doi.org/10.1016/S0022-3476(75)80599-3Get rights and content

Infants with IRDS were treated with CPAP early (0.40 FiO2<60 mm Hg) or late (0.70 FiO2; PaO2 <60 mm Hg). There was no difference in survival, duration of CPAP therapy, total time of oxygen administration, or complications. The early treated infants needed a lower FiO2 (maximum 0.55) and had a less severe clinical course. The late treated infants were subjected to 0.70 or more FiO2 for an average of 24 hours and were in greater than 0.40 FiO2 significantly longer than those given CPAP early. Infants who weighed less than 1,500 gm and had severe disease did not do well regardless of when CPAP was applied.

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Cited by (54)

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    Citation Excerpt :

    Nonetheless, some of these trials are of interest given today's controversy regarding when to use surfactant if CPAP is applied early. In a 1976 report, Krouskop and colleagues [12] found no difference in survival or complications in infants assigned randomly to early (fraction of inspired oxygen [Fio2] requirement 0.40) or late CPAP (Fio2 requirement 0.70); however, these infants were large by today's standards (mean birth weight >1700 g). Similarly, Han and coworkers [13] found no differences in outcome in 82 infants less than 32 weeks' gestation who were randomly assigned to CPAP at birth or CPAP when Fio2 reached greater than 0.50.

  • Principles of Respiratory Monitoring and Therapy

    2005, Avery's Diseases of the Newborn
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    2002, Seminars in Neonatology
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Supported in part by United States Public Health Service Grant RR-00210.

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