Original articleMaternal barbiturate utilization and neonatal withdrawal symptomatology**
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Passive Addiction and Teratogenic Effects
2018, Volpe's Neurology of the NewbornTeratogenic study of phenobarbital and levamisole on mouse fetus liver tissue using biospectroscopy
2016, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :The prevalence of epilepsy in pregnant women has been reported to be about 0.3–0.6%, and PB therapy might induce a pattern of minor and major anomalies including congenital heart defects, cleft palate and developmental retardation in fetus. Combination use of PB with the other antiepileptic drugs especially diphenylhydantoin increases its teratogenic effects and causes “hydantoin syndrome” based on morphological after birth findings [14–22]. Several studies showed that the stimulation of maternal immune system can decrease or prevent drugs induced fetus anomalies.
Gender issues
2012, Handbook of Clinical NeurologyCitation Excerpt :Although the potential problem of neonatal withdrawal from AEDs is well recognized, there is little recent literature. Neonatal withdrawal from barbiturates occurred within 2–3 days following delivery, and included irritability, hypotonia, and vomiting (Desmond et al., 1972; Erith, 1975). Neonatal hypoglycemia after maternal valproate treatment was common (13/22 infants) in a prospective study, with the lowest blood glucose concentration being 1.0 nmol/L but all neonates were asymptomatic.
Epilepsy and Pregnancy
2011, Neurological Disorders and PregnancyMaternal Drug Abuse: Effects on the Fetus and Neonate
2011, Fetal and Neonatal Physiology E-Book, Fourth EditionEpilepsy and Pregnancy
2010, Neurological Disorders and Pregnancy
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Supported by the Maternal and Child Health Service, Maternity and Infant Care Project, No. 535, The John A. Hartford Foundation, Inc., and The American Legion Erna and Albert Siegmund Child Welfare and Rehabilitation Foundation.