Brief clinical and laboratory observationPropylene glycol: A potentially toxic vehicle in liquid dosage form
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Cited by (64)
Risk assessment of neonatal excipient exposure: Lessons from food safety and other areas
2014, Advanced Drug Delivery ReviewsCitation Excerpt :The manifestations of this include biochemical (increased anion gap and osmolar gap) and clinical (metabolic acidosis, seizures and coma). These have been documented in all human age groups when high doses of propylene glycol are administered [84–88,8,89–91]. In older age groups these references suggest that doses up to 1 g/kg/day are unlikely to cause acute adverse effects.
Propylene Glycol
2012, Small Animal Toxicology, Third EditionExcipients in medicinal products used in gastroenterology as a possible cause of side effects
2011, Regulatory Toxicology and PharmacologyCitation Excerpt :Rapid infusion of concentrated PG-containing drugs, has also been associated with respiratory depression, arrhythmias, hypotension, and seizure. Seizure and respiratory depression have also occurred in children after ingestion of oral liquid medicines containing PG (Arulanantham and Genel, 1978; Martin and Finberg, 1970). An observational study was recently published to document the neonatal exposure to the potentially harmful pharmaceutical excipients PG and benzyl alcohol present in parenteral medications (Shehab et al., 2009).
Propylene Glycol
2006, Small Animal ToxicologyPropylene Glycol
2005, Small Animal Toxicology