Necrotizing enterocolitis in premature infants1

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A syndrome consisting of vomiting, abdominal distention, gastrointestinal bleeding,and shock has been observed in premature infants. The disorder is usually fatal, and on postmortem examination, ulcerations are seen in the gastrointestinal tract, particularly the terminal ileum. History of maternal infection during delivery is significant. Anteand postmortem cultures in infants with enterocolitis reveal predominance of gramnegative organisms. Criteria for diagnosis are presented.

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    Supported in part by Fellowship Award1-F2-HD-20 819-01 from the National Institute of Child Health and Human Development and in part by donation of Mr. and Mrs. John I. B. McCulloch.

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