Kidney function in very low birth weight infants with furosemide-related renal calcifications at ages 1 to 2 years*,**
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2009, Kidney InternationalCitation Excerpt :The clinical implications of this experimental evidence are progressively emerging in the field. In addition, the increased incidence of tubular nephrocalcinosis in preterm infants may possibly occur from exposure of differentiating renal tubular epithelial cells following crystalluria caused by furosemide treatment.140,141 Moreover, tubular nephrocalcinosis has been seen in a large number of renal allografts, suggesting that ischemic injury resulting in increased expression of hyaluronic acid and osteopontin precedes crystal retention.142,143
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Supported by Children's Mercy Hospital Research and Education Endowment Fund, Kansas City, Missouri.
- **
Presented in part at the Annual Meeting of the American Pediatric Society and the Society for Pediatric Research, New Orleans, La. May 1991.
- *
Now at the Children's Rehabilitation Unit, University of Kansas Medical Center, Kansas City, Kan.