Mean arterial blood pressure changes in premature infants and those at risk for intraventricular hemorrhage*

https://doi.org/10.1016/S0022-3476(05)80700-0Get rights and content

Bedside microcomputer-derived, minute-to-minute mean arterial pressure (MAP) values during the first 48 hours of life were studied in 100 preterm babies with birth weight ≤1500 gm. In those babies (n=72) with no periventricular-intraventricular hemorrhage (PV-IVH) or with grade 1 PV-IVH, the MAP values increased during the study period, with minute-to-minute variation and interval undulation. The MAP values in those with birth weight>1000 gm were higher than in those of lower birth weight. Infants in whom grades 2 to 4 PV-IVH developed (n=28) had consistently lower MAP values during the study period. Minute-to-minute variability, expressed as the average of the coefficients of variation at 15-minute intervals, did not differ between birth weight groups, nor did they differ between the PV-IVH group and their matched control subjects. However, those with PV-IVH spent a greater percentage of time, with a coefficient of variation≥13% or <3%, than their matched control subjects spent (p<0.005). This study provides reference data for MAP changes in premature babies. The observed MAP changes in those with PV-IVH lend support to a significant role for MAP alterations in the pathogenesis of PV-IVH.

References (24)

  • VersmoldHT et al.

    Aortic blood pressure during the first 12 hours of life in infants with birth weight 610 to 4,200 grams

    Pediatrics

    (1981)
  • LevisonH et al.

    Blood pressure in normal full-term and premature infants

    Am J Dis Child

    (1966)
  • Cited by (255)

    • Cardiovascular Compromise in the Newborn Infant

      2023, Avery's Diseases of the Newborn
    • Intervention and Outcome for Neonatal Hypotension

      2020, Clinics in Perinatology
      Citation Excerpt :

      None of the infants with a mean BP greater than 30 mm Hg had severe lesions. In another study of 100 preterm infants in the first 48 hours of life with invasive BP recordings infants in whom grades 2 to 4 periventricular-IVH developed (n = 28) had consistently lower mean arterial pressure (MAP) than those who had no hemorrhage or a grade 1 hemorrhage only.44 Watkins and colleagues7 identified an association between prolonged duration of a mean BP less than the tenth percentile for birth weight and the frequency of IVH.

    View all citing articles on Scopus
    *

    Supported by National Institutes of Health (National Institute of Neurological and Communicative Disorders and Stroke) Program Project grant No. NS-21405.

    View full text