Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-α, interleukin-1β, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia☆,☆☆,★,★★,♢
Section snippets
Study design
A retrospective cohort study was conducted to examine the relationship between amniotic fluid concentrations of interleukin-6 (IL-6), TNF-α, IL-1β, and IL-8 and the occurrence of BPD in the neonate. The cohort consisted of women who were admitted to the Seoul National University Hospital with preterm labor, preterm premature rupture of membranes, or pregnancy-induced hypertension and who met the following criteria: (1) preterm singleton gestation (gestational age at birth ≤33 weeks); (2)
Results
Sixty-nine patients met the entry criteria of this study. BPD was diagnosed in 19% (13/69) of newborns. Table I compares the clinical characteristics of the study population according to the presence or absence of BPD. Neonates who developed BPD were delivered at lower gestational ages and had lower birth weights than those without this complication. However, no significant differences were found between these two groups in the prevalence of positive amniotic fluid cultures and significant
Comment
Our data clearly demonstrate that amniotic fluid concentrations of specific cytokines (IL-6, TNF-α, IL-1β, and IL-8) are significantly higher in fetuses who subsequently develop BPD than in those who do not develop BPD. For IL-6, IL-1β, and IL-8, this association remained significant after we adjusted for the effect of gestational age at birth. These results suggest that exposure to a prenatal inflammatory process, detectable by an elevated concentration of proinflammatory cytokines in amniotic
References (24)
- et al.
Pathophysiology and treatment of bronchopulmonary dysplasia
Pediatr Clin North Am
(1994) - et al.
Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease
J Pediatr
(1995) - et al.
Maternal blood C-reactive protein, white blood cell count, and temperature in preterm labor: a comparison with amniotic fluid white blood cell count
Obstet Gynecol
(1996) - et al.
A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes
Am J Obstet Gynecol
(1993) - et al.
Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1β, and tumor necrosis factor-α), neonatal brain white matter lesions, and cerebral palsy
Am J Obstet Gynecol
(1997) - et al.
Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity
Am J Obstet Gynecol
(1995) - et al.
Bronchopulmonary dysplasia: clinical presentation
J Pediatr
(1979) - et al.
Association of Ureaplasma urealyticum infection of the lower respiratory tract with chronic lung disease and death in very low birth weight infants
Lancet
(1988) - et al.
Perinatal mycoplasmal infections
Clin Perinatol
(1991) - et al.
Case-control study of antenatal and intrapartum risk factors for cerebral palsy in very preterm singleton babies
Lancet
(1995)
Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops
Pediatrics
The role of inflammation in the pathogenesis of bronchopulmonary dysplasia
Pediatr Pulmonol
Cited by (446)
Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment
2024, American Journal of Obstetrics and GynecologyBlockade of IL-6R prevents preterm birth and adverse neonatal outcomes
2023, eBioMedicineToward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified according to placental pathology
2022, American Journal of Obstetrics and GynecologyAmniotic fluid interleukin 6 and interleukin 8 are superior predictors of fetal lung injury compared with maternal or fetal plasma cytokines or placental histopathology in a nonhuman primate model
2021, American Journal of Obstetrics and GynecologyPerinatal origins of bronchopulmonary dysplasia—deciphering normal and impaired lung development cell by cell
2023, Molecular and Cellular Pediatrics
- ☆
From the Departments of Obstetrics and Gynecology and Pediatrics, College of Medicine, Seoul National University.
- ☆☆
Supported by grant No. 94-0403-11-3 from the Korea Science and Engineering Foundation (KOSEF) and grant No. 03-97-030 from the Seoul National University Hospital Research Fund.
- ★
Dr. Romero and Dr. Ghezzi have participated as private citizens, not as agents of the U.S. government or any of the universities to which they hold appointments.
- ★★
Reprint requests: Bo Hyun Yoon, MD, PhD, Department of Obstetrics and, Gynecology, Seoul National University Hospital, Seoul, 110-744, Korea.
- ♢
0002-9378/97 $5.00 + 0 6/6/84418