Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia☆,☆☆,★,★★
Section snippets
Study design
We examined the relationship between umbilical cord plasma TNF-α, IL-6, IL-1β, and IL-1ra concentrations and the occurrence of periventricular leukomalacia–associated white matter lesions occurring within 3 days of birth in 172 consecutive preterm neonates (gestational age <36 weeks) delivered at Seoul National University Hospital. Neonates were excluded if umbilical cord blood could not be obtained, if they had major congenital malformations, or if they died before the examination.
Umbilical cord plasma
Umbilical
RESULTS
Over the study period 281 preterm neonates (gestational age <36 weeks) were delivered. Among these, 96 were excluded (75 because blood could not be retrieved from the umbilical cord at birth and 21 because of congenital anomalies). Thirteen infants could not be evaluated for periventricular leukomalacia–associated lesions (two neonates who had abnormal periventricular white matter echogenicity in the first scan but died before 5 days after birth and 11 neonates who died in the delivery room
COMMENT
This is the first report to document a relationship between umbilical cord plasma IL-6 concentrations and the development of periventricular leukomalacia–associated lesions. Our data clearly demonstrate that periventricular leukomalacia–associated lesions occurred more frequently in newborns with detectable umbilical cord plasma IL-6 than in those without detectable IL-6 (21.2% [20/94] vs 6.4% [5/78]; p < 0.01]. Moreover, the logistic regression analysis demonstrated that the umbilical cord
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From the Departments of Obstetrics and Gynecology,a Radiology,b and Pediatrics,c College of Medicine, Seoul National University, and the Perinatology Branch, National Institute of Child Health and Human Development.d
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Supported by grant No. 94-0403-11-01-3 from the Korea Science and Engineering Foundation and grant No. 03-94-030 from the Seoul National University Hospital Research Fund.
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Reprint requests: Bo Hyun Yoon, MD, PhD, Department of Obstetrics and Gynecology, Seoul National University, Seoul, 110-744, Korea.
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