Original articlePostoperative analgesia and sedation following pediatric cardiac surgery using a constant infusion of ketamine☆
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2016, Smith's Anesthesia for Infants and Children, Ninth EditionPopulation pharmacokinetics of ketamine in children with heart disease
2015, International Journal of PharmaceuticsCitation Excerpt :However, CYP 3A4 has been shown to be the major contributor to ketamine metabolism (Hijazi and Boulieu, 2002). The high ketamine clearance rate suggests that its elimination is susceptible to factors affecting hepatic blood flow (Brunette et al., 2011; Hartvig et al., 1993; Malinovsky et al., 1996). Despite the common use of ketamine in children with cardiac disease, pharmacokinetic (PK) data in this population are sparse.
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Supported by grants from Parke-Davis, Division of Warner Lambert Company, Solna, Sweden.
Copyright © 1993 Published by Elsevier Inc.