Original contributionLipid peroxidation in human diseases: Evidence of red cell oxidative stress after circulatory shock
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2017, Free Radical Biology and MedicineCitation Excerpt :Indeed, erythrocytes, the most abundant cells in the human organism, are directly exposed to the biochemical milieu of plasma. In addition, the exposure to high concentrations of oxygen and haemoglobin, the absence of organelles including nucleus and mitochondria, incapacity to synthesize new proteins and detoxifying enzymes, make RBC extremely sensitive to oxidative damage with erythrocyte membrane particularly prone to undergo lipid peroxidation under OxS condition [118,120,1119]. This notion is in line with recent findings which showed a significant increase of MDA in RTT patients erythrocytes [76].
Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders
2017, Free Radical Biology and MedicineCitation Excerpt :HNE toxicity is mainly due to the resultant alterations of cell function secondary to the formation of covalent adducts with proteins [7]. HNE reactivity was detected at first by Schauenstein and Esterbauer in the late 1970s, with subsequent studies demonstrating its harmful effect towards biological components and its marked cytotoxicity [7–13]. Since the 1990s a link between neurodegenerative disorders and increased levels of lipid peroxidation (LPO) end products was established [2,3,14–16].
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