Sequences homologous to glutamic acid decarboxylase cDNA are present on mouse chromosomes 2 and 10
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Chapter 3 GAD65 Autoimmunity-Clinical Studies
2008, Advances in ImmunologyCitation Excerpt :Later, ICA was also reported at a high frequency in newly diagnosed T1D children (Lendrum et al., 1976). The pattern of staining revealed beta- (Gianani et al., 1992) or alpha-cell (Bottazzo and Lendrum, 1976)-specific patient sera. The beta-cell-specific pattern was later shown to be GAD65A specific (Marshall et al., 1994) while the autoantigen(s) of the alpha cell staining remains unresolved.
GABA and GABA receptors in the central nervous system and other organs
2002, International Review of CytologyCitation Excerpt :The two GAD isoforms are products of two distinct genes. The GAD65 gene is located on chromosome 10, and the GAD67 gene is located on chromosome 2 in human (Brilliant et al., 1990; Bu et al., 1992). In the brain, GAD67 is responsible for synthesis of > 90% of GABA, whereas the major GAD isoform in pancreatic B cells is GAD65 (Christgau et al., 1992).
Structural and pharmacological aspects of the GABA<inf>A</inf> receptor: Involvement in behavioral pathogenesis
1996, Journal of Physiology ParisTranscription and translation of two glutamate decarboxylase genes in the ileum of rat, mouse and guinea pig
1995, Journal of the Autonomic Nervous System
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