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Cited by (58)
Evaluations of Morphine and Fentanyl for Mechanically Ventilated Patients With Respiratory Disorders in Intensive Care: A Systematic Review of Methodological Trends and Reporting Quality
2019, Value in Health Regional IssuesCitation Excerpt :In the remaining 2 studies, the behavioral state of the neonates determined the outcome of sedation, with lower scores reflecting better sedated neonates.19,27 One study measured the duration of MV and mortality as other primary, but undefined, outcomes.29 Another primary outcome, neurodevelopmental function, measured cognitive and language function using the mental development index and gross motor development using the psychomotor development index.36
Clinical and Economic Analysis of Morphine Versus Fentanyl in Managing Ventilated Neonates With Respiratory Distress Syndrome in the Intensive Care Setting
2019, Clinical TherapeuticsCitation Excerpt :Referring to the RCT by Anand et al,19 however, the mortality rate was found to be comparable based on similar durations of analgesia between study groups.9 In Quinn et al,45 mortality among study groups, although not clearly defined, did not differ when followed, based on equal groups’ durations of therapy. Hence, the increased mortality with morphine in this study can be attributed to the large difference in the duration of analgesia observed (12 days with morphine over fentanyl).
Sedation and analgesia to facilitate mechanical ventilation
2013, Clinics in PerinatologyCitation Excerpt :Among the first to suggest clinical benefit, the NOPAIN trial reported decreased rates of periventricular leukomalacia, severe IVH, and death when morphine was prophylactically infused into mechanically ventilated premature neonates.65 Other small, randomized controlled trials reported improved ventilator synchrony and serum stress markers in response to morphine.28,29,111 In contrast, 2 large, placebo-controlled trials could not demonstrate the benefit of morphine for intubated neonates found in smaller trials.
Does neonatal morphine use affect neuropsychological outcomes at 8 to 9 years of age?
2013, PainCitation Excerpt :Follow-up of randomized controlled trials (RCT) helps to evaluate the effect of morphine on long-term outcomes. More than a decade ago, the first follow-up study [46] of 2 RCTs [53,54] in preterm infants on morphine, pancuronium, and placebo found no effect of neonatal morphine use on intelligence, visual motor integration, or behavior 5 to 6 years later. In a small pilot follow-up in 5- to 7-year-old children who had been mechanically ventilated after birth, those who had received morphine (n = 14) had comparable intelligence quotient (IQ) scores and academic achievements to those who had received placebo (n = 5).
A pilot study of preemptive morphine analgesia in preterm neonates: Effects on head circumference, social behavior, and response latencies in early childhood
2012, Neurotoxicology and TeratologyCitation Excerpt :Given the long-term neurological impact of untreated neonatal pain (Fitzgerald and Walker, 2009), it is essential to determine the long-term effects of preemptive analgesia. Several randomized trials have begun to evaluate the efficacy of preemptive analgesia in neonates; specifically, opiate and sedative treatment (e.g., Anand et al., 2004; Quinn et al., 1992, 1993; Roze et al., 2008). Three have described long-term outcomes of such analgesia (de Graaf et al., 2011; MacGregor et al., 1998; Roze et al., 2008).
Long-term effects of routine morphine infusion in mechanically ventilated neonates on children's functioning: Five-year follow-up of a randomized controlled trial
2011, PainCitation Excerpt :The one comparable previous study did not find adverse effects of neonatal morphine on the intelligence, motor function, and behavior of 5- to 6-year-old children [29]. This study differed from the present study with regard to the 5- to 10-fold higher morphine dosage, the induction of neuromuscular paralysis, and lack of an observational and validated pain assessment instrument [36,37]. A limitation of the MacGregor [29] study was that only overall IQ, overall motor ability, and overall behavior were analyzed.