Heme oxygenase induction by cadmium chloride: evidence for oxidative stress involvement
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Cadmium elicits alterations in mitochondrial morphology and functionality in C3H10T1/2Cl8 mouse embryonic fibroblasts
2020, Biochimica et Biophysica Acta - General SubjectsCitation Excerpt :Very similarly to what we observed, Giedt et al. [49] reported that, after 0.1 mM selenium administration, morphology of lung A459 cells showed a progressive shift from a networked to a punctuate and finally to a swollen phenotype. Swollen mitochondria were also observed in vivo in renal cortex [50] and in liver [51] of rats treated with cadmium. Another compensative mechanism, triggered by C3H10T1/2Cl8 mouse embryonic fibroblast cells upon exposure to cadmium, is autophagy induction.
Cytotoxic effects of cadmium and zinc co-exposure in PC12 cells and the underlying mechanism
2017, Chemico-Biological InteractionsCitation Excerpt :In addition, Cd2+ toxicity could be partly due to oxidative stress induced by ROS produced in the cells in response to metal ions [36,37]. Cd2+ induces the expression of hemeoxygenase enzyme, which generates ROS, in various cell types [38,39]. Some evidence suggests that Cd2+-MT complexes can induce ROS, which in turn cause DNA damage in cells [40].
Affinity chromatography of chaperones based on denatured proteins: Analysis of cell lysates of different origin
2016, Protein Expression and PurificationCitation Excerpt :Interaction of eukaryotic chaperonin (Hsp60) with the denatured lysozyme-based affinity sorbent was controlled using the mitochondrial fraction of rat liver cells in normal conditions and after oxidative stress (Fig. 6B). SDS gel electrophoresis of mitochondrial fractions of rat liver cells in normal conditions (control) and after the induction of oxidative stress by cadmium chloride [33], showed the presence of a large number of proteins with various molecular weights. It is obvious that the difference in the level of 60 kDa protein synthesis before and after oxidative stress can hardly be distinguished before affinity chromatography (Fig. 6B, lanes 3 and 4).
Nephroprotection of plantamajoside in rats treated with cadmium
2015, Environmental Toxicology and PharmacologyCitation Excerpt :In addition, Cd is a source shown to indirectly produce ROS. Heme oxygenase induction by Cd in cell is shown to contribute to generation of ROS (Müller et al., 1994; Ossola and Tomaro, 1995) also detected that Cd-metallothionein can induce ROS in vitro extracellular condition. Plantago asiatica (PA) has been traditionally used as a folk medicine (Chiang et al., 2003), and has anti-inflammatory and antioxidant activities to protect kidney against ferric nitrilotriacetic-induced renal injury.
Mitochondria, reactive oxygen species and cadmium toxicity in the kidney
2010, Toxicology LettersCadmium Intoxication of Pregnant Rats and Fetuses: Interactions of Copper Supplementation
2010, Archives of Medical ResearchCitation Excerpt :In the present study, except for the fetal kidney tissues, MPO activity was increased in all tissues exposed to Cd. Previous investigations have shown that Cd inhibits the activity of most antioxidant system enzymes (48,49). This probably leads to intracellular accumulation of ROS with subsequent development of tissue injury.