Potassium channel activation: A potential therapeutic approach?
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Anti-nociceptive mechanisms of flavonoids-rich methanolic extract from Terminalia coriacea (Roxb.) Wight & Arn. leaves
2018, Food and Chemical ToxicologyCitation Excerpt :Gossypetin modulates calcium channels (Gadotti et al., 2015). Luteolin is a potassium-ATP channel opener (Lawson, 1996). It was found to exhibit 8–16 folds more potent analgesic activity than the standard drugs like aspirin, indomethacin and paracetamol (Block et al., 1998).
Relaxant effect of flavonoid naringenin on contractile activity of rat colonic smooth muscle
2014, Journal of EthnopharmacologyAntinociceptive effect of ethanol extract of leaves of Lannea coromandelica
2014, Journal of EthnopharmacologyCitation Excerpt :Previous studies reports specific blockade of ATP-sensitive K+ channel by glibenclamide while not affecting other types of K+ channel like Ca2+ activated and voltage-gated K+ channels (Alves and Duarte, 2002; Jesse et al., 2007). The results of this study, therefore, might indicate the involvement of ATP sensitive K+ channel opening and subsequent efflux of K+ ion and membrane repolarization and/or hyperpolarization by EELC which reduces the membrane excitability (Lawson, 1996). In conclusion, the results of the present study indicate that EELC possesses significant antinociceptive activity that is prominent in chemical-induced pain models than heat-induced models.
Central and peripheral antinociceptive effects of ellagic acid in different animal models of pain
2013, European Journal of PharmacologyCitation Excerpt :There are many reports on the fact that glibenclamide specifically blockes ATP-sensitive K+ channels, with no effects on other types of K+ channels such as Ca2+ activated and voltage-gated potassium channels (Alves and Duarte, 2002; Jesse et al., 2007). Therefore, the present findings might suggest that EA exerted its antinociceptive activity through the opening of ATP-sensitive K+ channel that allows the efflux of K+ ion, thus leading to membrane repolarization and/or hyperpolarization state which reduces the membrane excitability (Lawson, 1996). Altogether, the present results provide strong evidence on the participation of retain-->l-arginine/NO/cGMP/ATP-sensitive K+ channel pathway in EA-induced antinociception.
Antinociceptive effect of the essential oil of Zingiber zerumbet in mice: Possible mechanisms
2011, Journal of EthnopharmacologyCitation Excerpt :There have been many reports on the fact that glibenclamide specifically blocked ATP-sensitive K+ channel, with no effects on other types of K+ channel such as Ca2+ activated K+ channel and voltage-gated potassium channels (Alves and Duarte, 2002; Jesse et al., 2007). Therefore, the present findings might suggest that EOZZ exerted its antinociceptive activity through the opening of ATP-sensitive K+ channel that allows the efflux of K+ ion, thus leading to membrane repolarization and/or hyperpolarization state which reduces the membrane excitability (Lawson, 1996). Altogether, the present findings provide strong evidence on the participation of l-arginine/NO/cGMP/ATP-sensitive K+ channel pathway in EOZZ-induced antinociceptive activity.
Discovery and structure-activity relationships of a novel series of benzopyran-based K<inf>ATP</inf> openers for urge urinary incontinence
2009, Bioorganic and Medicinal Chemistry